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BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (Internal Region)

Details for Product anti-BCL2L11 Antibody No. ABIN361749, Supplier: Log in to see
Antigen
  • 1500006F24Rik
  • BAM
  • Bim
  • bim
  • BIM
  • BIMEL
  • BimL
  • Bod
  • BOD
Alternatives
anti-Human BIM antibody for ELISA
Epitope
Internal Region
77
19
14
13
13
13
13
13
11
7
6
6
6
5
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
272
135
107
4
2
2
2
2
2
Host
Rabbit
245
15
14
13
7
Clonality
Polyclonal
Conjugate
This BIM antibody is un-conjugated
16
14
9
8
8
8
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
223
130
97
47
36
27
26
24
14
8
3
2
2
2
2
Supplier
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Immunogen Internal central amino acids of human Bim
Specificity Detects ~23 kDa.
Purification Protein A Purified
Alternative Name BIM/BOD (BCL2L11 Antibody Abstract)
Background Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1,2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1 ,2).
Cellular Localization: Mitochondrion | Endomembrane System
Gene ID 10018
NCBI Accession NP_619527
UniProt O43521
Pathways PI3K-Akt Signaling, Neurotrophin Signaling Pathway
Application Notes Recommended Dilution: WB (1:1000), IHC (1:100), optimal dilutions for assays should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
 image for anti-BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (Internal Region) (ABIN361749) Bim Bod (IN), Human Skin Cancer Cells.
Background publications Hsu, Lin, Hsueh: "BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members." in: Molecular endocrinology (Baltimore, Md.), Vol. 12, Issue 9, pp. 1432-40, 1998

OConnor, Strasser, OReilly, Hausmann, Adams, Cory, Huang: "Bim: a novel member of the Bcl-2 family that promotes apoptosis." in: The EMBO journal, Vol. 17, Issue 2, pp. 384-95, 1998