anti-BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (Internal Region)

Details for Product anti-BCL2L11 Antibody No. ABIN361749
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Antigen
Synonyms bim, BAM, BIM, BOD, 1500006F24Rik, Bim, Bod, BimL, BIMEL
Epitope
Internal Region
(80), (28), (15), (15), (12), (12), (12), (12), (9), (8), (8), (7), (7), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(308), (160), (122), (2)
Host
Rabbit
(275), (24), (19), (17), (7)
Clonality
Polyclonal
Conjugate
This BIM antibody is un-conjugated
(19), (17), (10), (10), (9), (9), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(252), (145), (109), (52), (43), (37), (33), (31), (16), (13), (9), (4), (3), (3), (3), (3)
Pubmed 2 references available
Quantity 25 μg
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Immunogen Internal central amino acids of human Bim
Specificity Detects ~23 kDa.
Purification Affinity Purified
Alternative Name BIM/BOD (BCL2L11 Antibody Abstract)
Background Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1,2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1 ,2).
Cellular Localization: Mitochondrion and Endomembrane System
Gene ID 10018
NCBI Accession NP_619527
UniProt O43521
Research Area Apoptosis/Necrosis
Pathways PI3K-Akt Signaling Pathway
Application Notes Recommended Dilution: WB (1:1000), IHC (1:50)
Optimal dilutions for assays should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (Internal Region) antibody Bim Bod (IN), Human Skin Cancer Cells.
Background publications Hsu, Lin, Hsueh: "BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members." in: Molecular endocrinology (Baltimore, Md.), Vol. 12, Issue 9, pp. 1432-40, 1998 (PubMed).

OConnor, Strasser, OReilly et al.: "Bim: a novel member of the Bcl-2 family that promotes apoptosis." in: The EMBO journal, Vol. 17, Issue 2, pp. 384-95, 1998 (PubMed).

Validation Images
Catalog No. ABIN361749
184.80 $
Plus shipping costs $45.00
Quantity
Price
25 μg
184.80 $

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