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BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) antibody
| Antigen | BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) |
| Synonyms | BAM, BIM, BOD, BimL, BimEL, BIM-beta6, BIM-beta7, BIM-alpha6, Bim, Bod, 1500006F24Rik, bim |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Mouse (Murine), Rat (Rattus) |
| Application |
Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
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| Catalog no. | ABIN361750 |
| Quantity | 100ug (1mg/mL) (Variants) |
| Price | 290.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 5 to 10 Business Days |
, Human Skin Cancer Cells.jpg)
, Bim in K562 (K) and A549 (A) whole cell lysates.jpg)
Additional Information
| Alternative name | Bim/Bod |
| Immunogen | Internal central amino acids of human Bim |
| Format | Affinity-purified |
| Description | Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1,2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1,2). |
| Specificity | Detects a 23 kD protein corresponding to the molecular mass of Bim on SDS PAGE immunoblots. Species cross-reactivity: Human, mouse, rat. |
Application Details
| Application Notes | Suggested dilution 1: 1000 for Western blots, 1:50 for IHC. |
| Concentration | 1mg/mL |
| Buffer | Affinity purified in PBS with 0.02% Sodium Azide |
| Storage | -20°C, 1 year+, shipped on cold packs or ambient |
| Restrictions | For Research Use only |
Images
| Bim-Bod (IN), Human Skin Cancer Cells Bim-BOD (IN), Bim in K562 (K) and A549 (A) whole cell lysates |
, Human Skin Cancer Cells.jpg)
, Bim in K562 (K) and A549 (A) whole cell lysates.jpg)
Alternatives
Alternatives for antigen "BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11)", type "Antibodies"
| Hosts | Rabbit (46), Mouse (6), Goat (4), Rat (4), Hamster (3) |
| Reactivities | Human (53), Mouse (Murine) (46), Rat (Rattus) (34), Monkey (3) |
| Applications | Western Blotting (WB) (51), Immunofluorescence (IF) (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (18), Immunohistochemistry (IHC) (11), Enzyme Immunoassay (EIA) (9), Flow Cytometry (FACS) (7), Immunoprecipitation (IP) (7), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), ELISA (4), Immunocytochemistry (ICC) (4) |
| Conjugates | Biotin (1) |
| Epitopes | pSer69/65 (4), N-Term (3), AA 2-198 (2), Center (2), pSer69 (2), BH3 Domain (1), C-Term (1), IN (1) |
