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BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (Intermediate Domain 2)

Details for Product anti-BCL2L11 Antibody No. ABIN361751, Supplier: Log in to see
Antigen
Alternatives
anti-Human BIM antibody for ELISA
Epitope
Intermediate Domain 2
77
20
14
13
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13
13
13
11
7
6
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3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
274
137
109
4
2
2
2
2
2
Host
Rabbit
247
15
14
13
7
Clonality
Polyclonal
Conjugate
This BIM antibody is un-conjugated
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14
9
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8
8
4
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3
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3
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3
3
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3
3
3
2
2
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2
2
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2
Application
Immunocytochemistry (ICC), Western Blotting (WB)
223
130
97
47
36
27
26
26
14
8
3
2
2
2
2
Supplier
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Immunogen Internal central AA of human Bim
Specificity Detects a 23 kDa protein corresponding to the molecular mass of Bim on SDS PAGE immunoblots.
Purification Affinity Purified
Alternative Name BIM/BOD (BCL2L11 Antibody Abstract)
Background Synonyms:
BCL2 like protein 11, Bcl2 interacting mediator of cell death antibody, Bcl2 interacting protein Bim, BCL2 like 11, BAM, BimEl, BimL, BOD, BIM beta 6, BIM Beta7, BIM alpha 3, BIM alpha4, BIM alpha5, BIM alpha6
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of approx. 23, 16, and 13 kDa, respectively.Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
Gene ID 10018
NCBI Accession NP_619527
UniProt O43521
Research Area Apoptosis/Necrosis
Pathways PI3K-Akt Signaling, Neurotrophin Signaling Pathway
Application Notes Recommended Dilution: 1:400 (WB), 1:100 (ICC)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
 image for anti-BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (Intermediate Domain 2) (ABIN361751) Bim BOD (IN2), K562 Cells.
Western Blotting (WB) image for anti-BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (Intermediate Domain 2) (ABIN361751) Bim Bod A549 Cell lysate 10ug WB 1 in 1000.
Background publications Hsu, Lin, Hsueh: "BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members." in: Molecular endocrinology (Baltimore, Md.), Vol. 12, Issue 9, pp. 1432-40, 1998 (PubMed).

OConnor, Strasser, OReilly et al.: "Bim: a novel member of the Bcl-2 family that promotes apoptosis." in: The EMBO journal, Vol. 17, Issue 2, pp. 384-95, 1998 (PubMed).