Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN361751

BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (Intermediate Domain 2) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms BAM, BIM, BOD, Bim, Bod, 1500006F24Rik, BimL, bim
Epitope
»Alternatives Intermediate Domain 2
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunocytochemistry (ICC)
Pubmed 2 references available
Catalog no. ABIN361751
Quantity 25 µg
Price
196.90 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 3 to 4 Business Days
Immunogen Internal central AA of human Bim
Specificity Detects a 23 kDa protein corresponding to the molecular mass of Bim on SDS PAGE immunoblots.
Purification Affinity Purified
Alternative Name BIM/BOD
Background Synonyms:
BCL2 like protein 11, Bcl2 interacting mediator of cell death antibody, Bcl2 interacting protein Bim, BCL2 like 11, BAM, BimEl, BimL, BOD, BIM beta 6, BIM Beta7, BIM alpha 3, BIM alpha4, BIM alpha5, BIM alpha6
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of approx. 23, 16, and 13 kDa, respectively.Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
Gene ID 10018
NCBI Accession NP_619527.1
UniProt O43521
Research Area Apoptosis/Necrosis
Application Notes Recommended Dilution: 1:400 (WB), 1:100 (ICC)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide
Preservative Sodium azide
Storage -20 °C
Background publications OConnor, Strasser, OReilly et al.: "Bim: a novel member of the Bcl-2 family that promotes apoptosis." in: The EMBO journal, Vol. 17, Issue 2, pp. 384-95, 1998 (PubMed).

Hsu, Lin, Hsueh: "BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members." in: Molecular endocrinology (Baltimore, Md.), Vol. 12, Issue 9, pp. 1432-40, 1998 (PubMed).

Alternatives for antigen "BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11)", type "Antibodies"
Hosts (151), (15), (12), (7), (3)
Reactivities (168), (128), (106), (37), (36), (24), (2), (1), (1)
Applications (124), (56), (48), (40), (37), (31), (20), (19), (16), (5), (5), (3), (3), (3)
Conjugates (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (21), (15), (12), (12), (9), (8), (4), (4), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Beacon