BCL2 like protein 11, Bcl2 interacting mediator of cell death antibody, Bcl2 interacting protein Bim, BCL2 like 11, BAM, BimEl, BimL, BOD, BIM beta 6, BIM Beta7, BIM alpha 3, BIM alpha4, BIM alpha5, BIM alpha6
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of approx. 23, 16, and 13 kDa, respectively.Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.