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BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (Internal Region) antibody

Antigen

BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11)
Synonyms BAM, BIM, BOD, BimL, BimEL, BIM-beta6, BIM-beta7, BIM-alpha6, Bim, Bod, 1500006F24Rik, bim
Binding Site
Alternatives

Internal Region
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunocytochemistry (ICC)
2 references available
Catalog no. ABIN361751
Quantity 25µg  (1mg/mL)  (Variants)
Price 192.50 $   Plus shipping costs $45.00
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anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (Internal Region) antibody

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (Internal Region) antibody (2)

Additional Information
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Alternative name BIM/BOD
Gene ID 10018
UniProt O43521
Immunogen Internal central amino acids of human Bim
Description Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
Synonyms: BCL2 like protein 11, Bcl2 interacting mediator of cell death antibody, Bcl2 interacting protein Bim, BCL2 like 11, BAM, BimEl, BimL, BOD, BIM beta 6, BIM Beta7, BIM alpha 3, BIM alpha4, BIM alpha5, BIM alpha6
Characteristics Accession Number: NP_619527.1
Specificity Detects a 23kDa protein corresponding to the molecular mass of Bim on SDS PAGE immunoblots.

Application Details
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Application Notes 1:400 (WB), 1:100 (ICC)
Concentration 1mg/mL
Purification Affinity purified
Buffer PBS
Preservative 0.02% sodium azide
Storage Store at -20° C. Shipping Temperature: Blue Ice or 4° C
Research Area Apoptosis/Necrosis
Restrictions For Research Use only

Publications
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OConnor, Strasser, OReilly et al.: "Bim: a novel member of the Bcl-2 family that promotes apoptosis." in: The EMBO journal, Vol. 17, Issue 2, pp. 384-95, 1998 (PubMed).

Hsu, Lin, Hsueh: "BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members." in: Molecular endocrinology (Baltimore, Md.), Vol. 12, Issue 9, pp. 1432-40, 1998 (PubMed).

Alternatives
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Alternatives for antigen "BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11)", type "Antibodies"
Hosts Rabbit (130), Hamster (5), Rat (5), Mouse (3)
Reactivities Human (129), Mouse (Murine) (95), Rat (Rattus) (85), Cow (Bovine) (54), Dog (Canine) (54), Sheep (Ovine) (54), Horse (Equine) (36), Pig (Porcine) (36), Monkey (1)
Applications Western Blotting (WB) (72), Immunofluorescence (IF) (64), Immunohistochemistry (IHC) (35), ELISA (31), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (21), Immunocytochemistry (ICC) (15), Immunoprecipitation (IP) (15), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (12), Flow Cytometry (FACS) (11), Immunoelectron Microscopy (IEM) (4), Dot Blot (Dot) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Fluor 350 (4), Alexa Fluor 488 (4), Alexa Fluor 555 (4), Alexa Fluor 647 (4), Biotin (4), Cy3 (4), Cy5 (4), Cy5.5 (4), Cy7 (4), FITC (4), Gold (4), HRP (4), PE (4), PE,Cy3 (4), PE,Cy5 (4), PE,Cy5.5 (4), PE,Cy7 (4)
Epitopes pSer69 (20), Middle Region (19), pSer55 (18), pSer87 (18), Internal Region (9), N-Term (6), AA 22-40 (4), Ser69 (3), pSer59,Internal Region (3), pSer65, pSer69 (3), pSer65 (2), AA 145-165 (1), AA 20-40 (1), BH3 Domain (1), Center (1), Internal Region,AA 140-169 (1), Middle Region 2 (1), Ser65, Ser69 (1), pSer69,pSer65 (1)