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Details for Product No. ABIN361753

BCL2 Binding Component 3 (BBC3) (N-Term) antibody

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Antigen
Synonyms JFY-1, JFY1, PUMA, PUMA/JFY1, Puma, BBC3
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN361753
Quantity 25 µg
Price
259.91 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen N-terminal AA of human PUMA
Specificity Detects a approx. 23 kDa protein corresponding to the molecular mass of PUMA on SDS PAGE immunoblots. 16 kDa bands may be seen in some instances, possibly corresponding to PUMAβ.
Purification Affinity Purified
Alternative Name PUMA
Background Synonyms:
BBC3, BCL2 binding component 3, p53 up regulated modulator of apoptosis, PUMA/JFY1
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 up-regulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-α and PUMA-β. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Gene ID 27113
NCBI Accession NP_001120712.1
UniProt Q9BXH1
Research Area Cancer, Apoptosis/Necrosis, Metabolism
Application Notes Recommended Dilution: 1:500 (WB), 1:100 (ICC)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide
Preservative Sodium azide
Storage -20 °C
Background publications Yu, Zhang, Hwang et al.: "PUMA induces the rapid apoptosis of colorectal cancer cells." in: Molecular cell, Vol. 7, Issue 3, pp. 673-82, 2001 (PubMed).

Nakano, Vousden: "PUMA, a novel proapoptotic gene, is induced by p53." in: Molecular cell, Vol. 7, Issue 3, pp. 683-94, 2001 (PubMed).

Han, Flemington, Houghton et al.: "Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11318-23, 2001 (PubMed).

Alternatives for antigen "BCL2 Binding Component 3 (BBC3)", type "Antibodies"
Hosts (76), (10), (2)
Reactivities (82), (22), (12), (12), (12), (12)
Applications (78), (15), (11), (10), (10), (5), (5), (5), (4), (1), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (14), (8), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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