Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) antibody

Antigen: Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C)

Synonyms: TS, CACH2, CACN2, CaV1.2, CCHL1A1, CACNL1A1, MGC120730

Clonality: Monoclonal (S57-46)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

Catalog no.: ABIN361759

Additional Information

Alternative name: Cav1.2

Immunogen: Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2, accession number P15381

Format: Protein G purified

Isotype: IgG1  (Matching secondary antibodies)

Clone: S57-46

Description: Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane.

Specificity: ~240kDa (varies with cell background due to glycosylation). Species cross-reactivity: Human, Mouse, Rat.

Application Details

Application Notes: WB: 1-10ug/mL (if results are off, try using the lysate without boiling), IHC/ICC: 0.1-1.0ug/mL (Perox), 1.0-10ug/mL (IF)

Concentration: 1mg/mL

Buffer: Protein G Purified. In PBS pH7.4, 50% glycerol and 0.09% sodium azide.

Storage: -20°C, 1 year+, shipped on cold packs or ambient

Restrictions: For Research Use only

Images

Cav1 2(S57-46) IP from INS-1E cells stained with anti-Cav1.2 poly

Cav1.2 (S57-46), Mouse brain tissue, Amplifier

Cav1.2 (S57-46) in Cav1.2-beta2-alpha2delta in T-CHO

Publications

Publications: Splawski, Nishioka, Nishioka et al.: "CD40 ligand is expressed and functional on activated neonatal T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 1, pp. 119-27, 1996 (PubMed).

Krey, Moussay, Thiel et al.: "Role of the low-density lipoprotein receptor in entry of bovine viral diarrhea virus." in: Journal of virology, Vol. 80, Issue 21, pp. 10862-7, 2006 (PubMed).

Crotti, Celano, Dagradi et al.: "Congenital long QT syndrome." in: Orphanet journal of rare diseases, Vol. 3, pp. 18, 2008 (PubMed).