Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) antibody

Antigen: Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C)

Synonyms: TS, CACH2, CACN2, CaV1.2, CCHL1A1, CACNL1A1, MGC120730

Clonality: Monoclonal (S48A-9)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Catalog no.: ABIN361760

Additional Information

Alternative name: Cav1.2

Immunogen: Fusion protein amino acids 859-875 of rat Cav1.3, accession numbr P27732

Format: Protein G purified

Isotype: IgG2a-kappa  (Matching secondary antibodies)

Clone: S48A-9

Description: Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane.

Specificity: ~250kDa. No cross-reactivity against Cav1.2. Species cross-reactivity: Human, Mouse, Rat.

Application Details

Application Notes: WB: 1-10ug/mL (if results are off, try using the lysate without boiling), IHC/ICC: 0.1-1.0ug/mL (Perox), 1.0-10ug/mL (IF)

Concentration: 1mg/mL

Buffer: Protein G Purified. In PBS pH7.4, 50% glycerol and 0.09% sodium azide.

Storage: -20°C, 1 year+, shipped on cold packs or ambient

Restrictions: For Research Use only

Images

Cav1.3 (S48A-9), Human hippocampus

Cav1.3 (S48A-9), human cell line mix

Cav1.3 (S48A-9), Mouse backskin

Publications

Publications: Zhang, He, Tuteja et al.: "Functional roles of Cav1.3(alpha1D) calcium channels in atria: insights gained from gene-targeted null mutant mice." in: Circulation, Vol. 112, Issue 13, pp. 1936-44, 2005 (PubMed).

Johnson, Marcotti: "Biophysical properties of CaV1.3 calcium channels in gerbil inner hair cells." in: The Journal of physiology, Vol. 586, Issue 4, pp. 1029-42, 2008 (PubMed).