Cav1.3 antibody

Antigen: Cav1.3

Clonality: Monoclonal (S38-8)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Catalog no.: ABIN361761

Additional Information

Immunogen: Fusion protein amino acids 2025-2161 of rat Cav1.3, accession number P27732

Format: Protein G purified

Isotype: IgG1  (Matching secondary antibodies)

Clone: S38-8

Description: Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane.

Specificity: ~250kDa. No cross-reactivity against Cav1.2. Species cross-reactivity: Human, Mouse, Rat.

Application Details

Application Notes: WB: 1-10ug/mL (if results are off, try using the lysate without boiling), IHC/ICC: 0.1-1.0ug/mL (Perox), 1.0-10ug/mL (IF)

Concentration: 1mg/mL

Buffer: Protein G Purified. In PBS pH7.4, 50% glycerol and 0.09% sodium azide.

Storage: -20°C, 1 year+, shipped on cold packs or ambient

Restrictions: For Research Use only

Images

Cav1.3 (S38-8), Human hippocampus

Cav1.3(S38-8), rat tissue lysate

Publications

Publications: Zhang, He, Tuteja et al.: "Functional roles of Cav1.3(alpha1D) calcium channels in atria: insights gained from gene-targeted null mutant mice." in: Circulation, Vol. 112, Issue 13, pp. 1936-44, 2005 (PubMed).

Johnson, Marcotti: "Biophysical properties of CaV1.3 calcium channels in gerbil inner hair cells." in: The Journal of physiology, Vol. 586, Issue 4, pp. 1029-42, 2008 (PubMed).