Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H) antibody

Antigen: Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H)

Clonality: Monoclonal (S55-10)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Catalog no.: ABIN361762

Additional Information

Alternative name: Cav3.2

Immunogen: Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3.2, accession number )95180

Format: Protein G purified

Isotype: IgG1  (Matching secondary antibodies)

Clone: S55-10

Description: Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane.

Specificity: ~260kDa. No cross-reactivity against Cav1.3. Species cross-reactivity: Human.

Application Details

Application Notes: WB: 1-10ug/mL (if results are off, try using the lysate without boiling), IHC/ICC: 0.1-1.0ug/mL (Perox), 1.0-10ug/mL (IF)

Concentration: 1mg/mL

Buffer: Protein G Purified. In PBS pH7.4, 50% glycerol and 0.09% sodium azide.

Storage: -20°C, 1 year+, shipped on cold packs or ambient

Restrictions: For Research Use only

Images

Cav3.2 (S55-10), Human hippocampus

Publications

Publications: Chen, Lu, Pan et al.: "Association between genetic variation of CACNA1H and childhood absence epilepsy." in: Annals of neurology, Vol. 54, Issue 2, pp. 239-43, 2003 (PubMed).

Khosravani, Altier, Simms et al.: "Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy." in: The Journal of biological chemistry, Vol. 279, Issue 11, pp. 9681-4, 2004 (PubMed).

Gackiuere, Bidaux, Delcourt et al.: "CaV3.2 T-type calcium channels are involved in calcium-dependent secretion of neuroendocrine prostate cancer cells." in: The Journal of biological chemistry, Vol. 283, Issue 15, pp. 10162-73, 2008 (PubMed).