Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) antibody

Antigen: Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4)

Synonyms: DFNA2, KV7.4, DFNA2A, KCNQ4, kv7.4, k(v)7.4, MGC146308

Clonality: Monoclonal (S43-6)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Catalog no.: ABIN361768

Additional Information

Characteristics: Detects ~77kDa.

Alternative name: KCNQ4

Gene ID: 9132

Swiss-Prot: P56696

Immunogen: Fusion protein amino acids 2-77 of human KCNQ4, accession number P56696

Format: Liquid

Isotype: IgG1  (Matching secondary antibodies)

Clone: S43-6

Description: Specifically, the protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anticonvulsant drug.
Synonyms: DFNA2, KQT like 4, Kv7.4, voltage gated potassium channel subunit Kv7.4

Specificity: ~77kDa. Species cross-reactivity: Human, Mouse, Rat.

Sensitivity: 1 µg/mL of SMC-309 was sufficient for detection of KCNQ4 in 10µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Application Details

Application Notes: 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Concentration: 1 mg/mL

Purification: Protein G Purified

Buffer: PBS pH7.4, 50% glycerol

Storage: -20 °C

Storage Shipping Temp Max: Blue Ice or 4 °C

Restrictions: For Research Use only

Images

KCNQ4 (S43-6), Human hippocampus

KCNQ4 (S43-6), rat tissue lysate

Publications

Publications: Tatulian, Delmas, Abogadie et al.: "Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 15, pp. 5535-45, 2001 (PubMed).

Kharkovets, Dedek, Maier et al.: "Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness." in: The EMBO journal, Vol. 25, Issue 3, pp. 642-52, 2006 (PubMed).

Hernandez, Zaika, Tolstykh et al.: "Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications." in: The Journal of physiology, Vol. 586, Issue 7, pp. 1811-21, 2008 (PubMed).