Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) antibody
| Antigen |
|
| Synonyms |
DFNA2, KV7.4, DFNA2A, KCNQ4, kv7.4, k(v)7.4, MGC146308 |
| Clonality |
Monoclonal (S43-6) |
|
Host
|
|
|
Reactivity
|
|
|
Application
|
Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
|
| Catalog no. |
ABIN361768 |
| Quantity |
100ug (1mg/mL) |
| Price |
357.50 $ Plus shipping costs $45.00
|
|
Bulk discount
|
| Shipping to |
|
| Availability |
Will be delivered in 3 to 4 Business Days |
|
Alternative name
|
KCNQ4
|
|
Gene ID
|
9132
|
|
UniProt
|
P56696
|
|
Immunogen
|
Fusion protein amino acids 2-77 of human KCNQ4, accession number P56696
|
|
Isotype
|
IgG1
|
|
Clone
|
S43-6
|
|
Description
|
Specifically, the protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anticonvulsant drug.
Synonyms: DFNA2, KQT like 4, Kv7.4, voltage gated potassium channel subunit Kv7.4
|
|
Characteristics
|
Accession Number: NP_004691.2
|
|
Specificity
|
Detects ~77kDa.
|
|
Sensitivity
|
1 µg/mL of SMC-309 was sufficient for detection of KCNQ4 in 10µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
|
|
Application Notes
|
1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)
|
|
Concentration
|
1mg/mL
|
|
Purification
|
Protein G Purified
|
|
Buffer
|
PBS pH7.4, 50% glycerol
|
|
Storage
|
Store at -20° C. Shipping Conditions: Blue Ice or 4° C
|
|
Storage Shipping Temp Max
|
Blue Ice or 4 °C
|
|
Research Area
|
Channels, Transporters, Neurology
|
|
Restrictions
|
For Research Use only
|
|
|
Tatulian, Delmas, Abogadie et al.: "Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 15, pp. 5535-45, 2001 (PubMed).
Kharkovets, Dedek, Maier et al.: "Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness." in: The EMBO journal, Vol. 25, Issue 3, pp. 642-52, 2006 (PubMed).
Hernandez, Zaika, Tolstykh et al.: "Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications." in: The Journal of physiology, Vol. 586, Issue 7, pp. 1811-21, 2008 (PubMed).
|
Alternatives for antigen "Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4)", type "Antibodies"
|
Hosts
|
Rabbit (12), Mouse (8), Goat (3)
|
|
Reactivities
|
Human (19), Mouse (Murine) (7), Rat (Rattus) (4)
|
|
Applications
|
Western Blotting (WB) (23), Immunohistochemistry (IHC) (10), ELISA (9), Immunocytochemistry (ICC) (4), Immunoprecipitation (IP) (3), Immunofluorescence (IF) (2), Immunostaining (ISt) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
|
|
Epitopes
|
C-Term (4), AA 2-77 (2), Internal Region (2), N-Term (2)
|