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Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) antibody
| Antigen | Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) |
| Synonyms | DFNA2, KV7.4, DFNA2A, KCNQ4, kv7.4, k(v)7.4, MGC146308 |
| Clonality | Monoclonal (S43-6) |
| Host |
Alternatives Mouse |
| Reactivity |
Alternatives Human, Mouse (Murine), Rat (Rattus) |
| Application |
Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
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3 references available |
| Catalog no. | ABIN361768 |
| Quantity | 100µg (1 mg/mL) |
| Price | 325.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Characteristics | Detects ~77kDa. |
| Alternative name | KCNQ4 |
| Gene ID | 9132 |
| Swiss-Prot | P56696 |
| Immunogen | Fusion protein amino acids 2-77 of human KCNQ4, accession number P56696 |
| Format | Liquid |
| Isotype | IgG1 (Matching secondary antibodies) |
| Clone | S43-6 |
| Description |
Specifically, the protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anticonvulsant drug. Synonyms: DFNA2, KQT like 4, Kv7.4, voltage gated potassium channel subunit Kv7.4 |
| Specificity | ~77kDa. Species cross-reactivity: Human, Mouse, Rat. |
| Sensitivity | 1 µg/mL of SMC-309 was sufficient for detection of KCNQ4 in 10µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
Application Details
| Application Notes | 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF) |
| Concentration | 1 mg/mL |
| Purification | Protein G Purified |
| Buffer | PBS pH7.4, 50% glycerol |
| Storage | -20 °C |
| Storage Shipping Temp Max | Blue Ice or 4 °C |
| Restrictions | For Research Use only |
Publications
| Publications |
Tatulian, Delmas, Abogadie et al.: "Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 15, pp. 5535-45, 2001 (PubMed).
Kharkovets, Dedek, Maier et al.: "Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness." in: The EMBO journal, Vol. 25, Issue 3, pp. 642-52, 2006 (PubMed). Hernandez, Zaika, Tolstykh et al.: "Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications." in: The Journal of physiology, Vol. 586, Issue 7, pp. 1811-21, 2008 (PubMed). |
Alternatives
Alternatives for antigen "Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4)", type "Antibodies"
| Hosts | Mouse (6), Goat (3), Rabbit (3) |
| Reactivities | Human (10), Mouse (Murine) (3), Rat (Rattus) (3) |
| Applications | Western Blotting (WB) (12), Enzyme Immunoassay (EIA) (4), Immunohistochemistry (IHC) (3), ELISA (2), Immunoprecipitation (IP) (2), Immunocytochemistry (ICC) (1), Immunofluorescence (IF) (1) |




Alternatives