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KCNQ4 antibody (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4) (AA 2-77)

Details for Product anti-KCNQ4 Antibody No. ABIN361768, Supplier: Log in to see
Antigen
  • KCNQ4
  • k(v)7.4
  • kv7.4
  • DFNA2
  • DFNA2A
  • KV7.4
  • potassium voltage-gated channel, KQT-like subfamily, member 4
  • potassium voltage-gated channel, subfamily Q, member 4
  • KCNQ4
  • kcnq4
  • Kcnq4
Alternatives
anti-Human KCNQ4 antibody for ELISA
Epitope
AA 2-77
37
11
10
7
5
2
2
2
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
99
53
48
2
2
1
1
1
1
Host
Mouse
67
18
16
Clonality (Clone)
Monoclonal ()
Conjugate
This KCNQ4 antibody is un-conjugated
5
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Antibody Array (AA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
99
57
52
51
42
34
17
14
2
2
1
1
Options
Supplier
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Available images

Immunogen Fusion protein amino acids 2-77 of human KCNQ4
Clone S43-6
Isotype IgG1
Specificity Detects ~77 kDa.
Sensitivity 1 µg/mL of SMC-309 was sufficient for detection of KCNQ4 in 10 µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name KCNQ4 (KCNQ4 Antibody Abstract)
Background The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability (1), particularly in sensory cells of the cochlea (2). The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug (3).
Gene ID 9132
NCBI Accession NP_004691
UniProt P56696
Research Area Neurology
Pathways Sensory Perception of Sound
Application Notes
  • WB (1:1000)
  • IHC (1:1000)
  • ICC/IF (1:100)
  • optimal dilutions for assays should be determined by the user.
Comment

1 μg/ml of SMC-309 was sufficient for detection of KCNQ4 in 10 μg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
 image for anti-KCNQ4 antibody (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4) (AA 2-77) (ABIN361768) KCNQ4 (S43 6), rat tissue lysate.
Background publications Hernandez, Zaika, Tolstykh, Shapiro: "Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications." in: The Journal of physiology, Vol. 586, Issue 7, pp. 1811-21, 2008 (PubMed).

Kharkovets, Dedek, Maier, Schweizer, Khimich, Nouvian, Vardanyan, Leuwer, Moser, Jentsch: "Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness." in: The EMBO journal, Vol. 25, Issue 3, pp. 642-52, 2006 (PubMed).

Tatulian, Delmas, Abogadie, Brown: "Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 15, pp. 5535-45, 2001 (PubMed).

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