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KIR2.2 antibody

Antigen

KIR2.2
Clonality Monoclonal (S124B-38)
Host

Mouse
Reactivity

Human, Mouse (Murine), Rat (Rattus)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
1 reference available
Catalog no. ABIN361770
Quantity 100µg  (1 mg/mL)
Price 325.00 $   Plus shipping costs $35.00
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anti-KIR2.2 antibody

anti-KIR2.2 antibody (2)

anti-KIR2.2 antibody (3)

Additional Information
Application Details Publications Images Secondary Antibodies back to top

Characteristics Detects ~45kDa. No cross-reactivity against Kir2.1 or Kir2.3
Gene ID 117052
Swiss-Prot Q6U7SO
Immunogen Fusion protein amino acids 362-427 of rat Kir2.2, accession number NP_446433
Format Liquid
Isotype IgG1  (Matching secondary antibodies)
Clone S124B-38
Description Kir2.2 participates in establishing action potential waveform and excitability of neuronal and muscle tissues. This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17.
Synonyms: IRK2, KCNJ12, kcnj12x, KCNJN1, Kir2.2v, potassium inwardly rectifying channel subfamily J member 12
Specificity ~45kDa. No cross reactivity against Kir2.1, or Kir2.3. Species cross-reactivity: Human, Mouse, Rat.
Sensitivity 1 µg/mL of SMC-311 was sufficient for detection of Kir2.2 in 30µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Application Details
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Application Notes 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)
Concentration 1 mg/mL
Purification Protein G Purified
Buffer PBS pH7.4, 50% glycerol
Storage -20 °C
Storage Shipping Temp Max Blue Ice or 4 °C
Restrictions For Research Use only

Publications
Application Details Images Secondary Antibodies back to top

Publications Zobel, Cho, Nguyen et al.: "Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2." in: The Journal of physiology, Vol. 550, Issue Pt 2, pp. 365-72, 2003 (PubMed).