KCNJ4 antibody (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 4) (AA 390-445)

Details for Product anti-KCNJ4 Antibody No. ABIN361771, Supplier: Log in to see
Antigen
  • KCNJ4
  • CKIR2.3
  • HIR
  • HIRK2
  • HRK1
  • IRK-3
  • IRK3
  • Kir2.3
  • Kcnf2
  • MB-IRK3
  • Hirk2
  • potassium inwardly-rectifying channel, subfamily J, member 4
  • KCNJ4
  • Kcnj4
Epitope
AA 390-445
39
18
11
3
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
71
52
51
2
2
2
2
1
1
Host
Mouse
45
32
Clonality (Clone)
Monoclonal ()
Conjugate
This KCNJ4 antibody is un-conjugated
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
1
1
Application
Antibody Array (AA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
75
42
39
38
23
20
18
17
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Fusion protein amino acids 390-445 of human Kir2.3
Clone S25-35
Isotype IgG1
Specificity Detects ~45 kDa. No cross-reactivity against Kir2.1 or Kir2.2.
Purification Protein G Purified
Alternative Name Kir2.3 (KCNJ4 Antibody Abstract)
Background Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene (1-3).
Gene ID 3761
NCBI Accession NP_004972
UniProt P48050
Application Notes
  • WB (1:1000)
  • IHC (1:1000)
  • ICC/IF (1:100)
  • optimal dilutions for assays should be determined by the user.
Comment

1 μg/ml of SMC-312 was sufficient for detection of Kir2.3 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
 image for anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 4 (KCNJ4) (AA 390-445) antibody (ABIN361771) Kir2.3 (S25-35), Human hippocampus
Background publications Muñoz, Vaidyanathan, Tolkacheva, Dhamoon, Taffet, Anumonwo: "Kir2.3 isoform confers pH sensitivity to heteromeric Kir2.1/Kir2.3 channels in HEK293 cells." in: Heart rhythm : the official journal of the Heart Rhythm Society, Vol. 4, Issue 4, pp. 487-96, 2007 (PubMed).

Panama, McLerie, Lopatin: "Heterogeneity of IK1 in the mouse heart." in: American journal of physiology. Heart and circulatory physiology, Vol. 293, Issue 6, pp. H3558-67, 2007 (PubMed).

Zobel, Cho, Nguyen, Pekhletski, Diaz, Wilson, Backx: "Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2." in: The Journal of physiology, Vol. 550, Issue Pt 2, pp. 365-72, 2003 (PubMed).

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