Cav Beta4 antibody

Antigen: Cav Beta4

Clonality: Monoclonal (S10-7)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

Catalog no.: ABIN361777

Additional Information

Immunogen: Synthetic peptide amino acids 458-474 of rat CavB4

Format: Protein G purified

Isotype: IgG1  (Matching secondary antibodies)

Clone: S10-7

Description: Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane.

Specificity: ~50kDa. No cross reactivity against rat Cav

Application Details

Application Notes: WB: 1-10ug/mL (if results are off, try using the lysate without boiling), IHC/ICC: 0.1-1.0ug/mL (Perox), 1.0-10ug/mL (IF)

Concentration: 1mg/mL

Buffer: Protein G Purified. In PBS pH7.4, 50% glycerol and 0.09% sodium azide.

Storage: -20°C, 1 year+, shipped on cold packs or ambient

Restrictions: For Research Use only

Images

Cavbeta4 (S10-7), T-CHO induced

CavBeta4 (S10-7), Human Hippocampus

Publications

Publications: Xie, Li, Han et al.: "Facilitation versus depression in cultured hippocampal neurons determined by targeting of Ca2+ channel Cavbeta4 versus Cavbeta2 subunits to synaptic terminals." in: The Journal of cell biology, Vol. 178, Issue 3, pp. 489-502, 2007 (PubMed).