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Details for Product No. ABIN361790

Discs, Large Homolog 3 (Drosophila) (DLG3) (AA 1-120) antibody

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Antigen
Synonyms MRX, MRX90, NEDLG, SAP102, XLMR, fa66c08, fa66e02, fd02c12, fu95c12, im:7138640, si:ch211-276g21.1, wu:fa66c08, wu:fa66e02, wu:fd02c12, wu:fu95c12, MPP3, Dlgh3
Epitope
»Alternatives AA 1-120
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Pubmed 3 references available
Catalog no. ABIN361790
Quantity 25 µg
Price
156.20 $   Plus shipping costs $45.00
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Immunogen Fusion protein AA 1-120 of rat SAP102
Clone S19-2
Isotype IgG1
Specificity Detects approx. 105 kDa.
Cross-Reactivity (Details) No cross-reactivity against PSD95, SAP97 or Chapsyn-110.
Sensitivity 1 µg/ml was sufficient for detection of Sap102 in 10 µg of rat brainlysate by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.
Purification Protein G Purified
Alternative Name SAP102
Background Synonyms:
DLG3, MRX90, NEDLG, XLMR
Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal. SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homology 3 domain and a guanylate kinase domain. All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from thepostsynaptic membrane by inhibiting the ERK/MAPK pathway. SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains.In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
Gene ID 58948
NCBI Accession NP_113827.1
UniProt Q62936
Research Area Neurology, Proliferation Markers, Organelles
Application Notes Recommended Dilution: WB: 1:1000 (ECL)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Storage -20 °C
Background publications Lau, Mammen, Ehlers et al.: "Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102." in: The Journal of biological chemistry, Vol. 271, Issue 35, pp. 21622-8, 1996 (PubMed).

Müller, Kistner, Kindler et al.: "SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo." in: Neuron, Vol. 17, Issue 2, pp. 255-65, 1996 (PubMed).

Cuthbert, Stanford, Coba et al.: "Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 10, pp. 2673-82, 2007 (PubMed).

Alternatives for antigen "Discs, Large Homolog 3 (Drosophila) (DLG3)", type "Antibodies"
Hosts (33), (18), (1)
Reactivities (39), (34), (26), (14), (13), (13), (13), (2), (1), (1)
Applications (42), (10), (9), (8), (8), (4), (4), (3), (2), (1), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (5), (3), (3), (3), (2), (2), (2), (1)
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