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Discs, Large Homolog 3 (Drosophila) (DLG3) (AA 1-120) antibody

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Synonyms Dlgh3, MRX, MRX90, NEDLG, SAP102, XLMR, mKIAA1232, fa66c08, fa66e02, fd02c12, fu95c12, im:7138640, si:ch211-276g21.1, wu:fa66c08, wu:fa66e02, wu:fd02c12, wu:fu95c12, MPP3
AA 1-120
(37), (7), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(58), (51), (38), (2), (2), (2), (1), (1), (1), (1), (1)
(52), (26), (1)
Clonality (Clone)
Monoclonal ()
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(75), (42), (42), (9), (5), (4), (4), (2), (2), (1), (1), (1), (1)
Pubmed 3 references available
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Quantity 100 μg
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Fusion protein amino acids 1-120 of rat SAP102
Clone S19-2
Specificity Detects ~105 kDa. No cross-reactivity against PSD95, SAP97 or Chapsyn-110.
Sensitivity 1 µg/ml was sufficient for detection of Sap102 in 10 µg of rat brainlysate by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.
Purification Protein G Purified
Alternative Name SAP102 (DLG3 Antibody Abstract)
Background Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal (1, 2). SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homology 3 domain and a guanylate kinase domain (3). All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway (3, 4). SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains (3). In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
Cellular Localization: Basolateral Cell Membrane | Cytoplasm | Cell Junction | Synapse | Postsynaptic Cell Membrane | Postsynaptic Density | Growth Cone
Gene ID 58948
NCBI Accession NP_113827
UniProt Q62936
Research Area Neurology, Proliferation Markers
Application Notes Recommended Dilution: WB (1:1000), optimal dilutions for assays should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
 image for anti-Discs, Large Homolog 3 (Drosophila) (DLG3) (AA 1-120) antibody (ABIN361791) Rat brain extract copy.
Background publications Cuthbert, Stanford, Coba et al.: "Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 10, pp. 2673-82, 2007 (PubMed).

Müller, Kistner, Kindler et al.: "SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo." in: Neuron, Vol. 17, Issue 2, pp. 255-65, 1996 (PubMed).

Lau, Mammen, Ehlers et al.: "Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102." in: The Journal of biological chemistry, Vol. 271, Issue 35, pp. 21622-8, 1996 (PubMed).

Catalog No. ABIN361791
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