p23 antibody

Antigen: p23

Clonality: Monoclonal (JJ6)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rabbit, Chicken, Yeast (Saccharomyces Cerevisiae)

Application: Western Blotting (WB), Immunoprecipitation (IP), ELISA

Catalog no.: ABIN361805

Additional Information

Characteristics: Detects ~23kDa.

Gene ID: 10728

Swiss-Prot: Q15185

Immunogen: Recombinant Human full length p23 protein

Format: Liquid

Isotype: IgG1  (Matching secondary antibodies)

Clone: JJ6

Description: P23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the hsp90 chaperoning system. Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure. p23 does not have any structural homology with any other known proteins. p23 was first discovered as a part of the Hsp90-progesterone receptor complex along with hsp70, p54 and p50. p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain. Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase, the heme regulated kinase HRI, hsf1 transcription factor, aryl hydrocarbon receptor, telomerase, and Hepadnavirus reverse transcriptase. In spite of several years of study, the exact functional significance of p23 is still not clear. p23 is thought to be involved in the adenosine triphosphate–mediated hsp90 binding of client proteins. Since many hsp90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis. Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
Synonyms: co chaperone p23, PTGES3, TEBP, telomerase binding protein p23, unactive progesterone receptor 23kDa

Sensitivity: 0.5µg/mL of SMC-156 was sufficient for detection of p23 in 20µg of heat shocked cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Application Details

Application Notes: 1:2000 (WB)

Concentration: 1 mg/mL

Purification: Protein G Purified

Buffer: PBS, 50% glycerol

Storage: -20 °C

Storage Shipping Temp Max: Blue Ice or 4 °C

Research Area: Cancer, Metabolism

Restrictions: For Research Use only

Images

P23 (JJ6) human cell line mix