Calnexin (N-Term) antibody
| Antigen |
|
| Clonality |
Polyclonal |
|
Host
|
|
|
Reactivity
|
 Alternatives Human, Mouse (Murine), Guinea Pig, Cow (Bovine), Chicken, Dog (Canine), Hamster, Pig (Porcine), Monkey, Rabbit, Sheep (Ovine), Xenopus laevis
Chicken (1), Cow (Bovine) (1), Dog (Canine) (1), Guinea Pig (1), Hamster (1), Human (1), Monkey (1), Mouse (Murine) (1), Pig (Porcine) (1), Rabbit (1), Sheep (Ovine) (1), Xenopus laevis (1)
|
|
Application
|
Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
|
| Catalog no. |
ABIN361839 |
| Quantity |
200ul (Variants) |
| Price |
359.00 $ Plus shipping costs $35.00
|
| Shipping to |
|
| Availability |
Ships within 7 to 10 Business Days |
|
Characteristics
|
Detects ~90kDa.
|
|
Gene ID
|
NP_001003232.1, 403908
|
|
Immunogen
|
A 19 residue synthetic peptide based on canine calnexin and the peptide coupled to KLH.
|
|
Format
|
Liquid
|
|
Description
|
Calnexin, an abundant ~90kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 (1). It consists of a large 50kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail (2, 3). Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention (4), calnexin has positively charged cytosolic residues that do the same thing (3). Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into mulit-subunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglycosylated glycans (5, 6). Calnexin has also been shown to associate with the major histocompatability complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin (7).
Synonyms: CANX, CNX, IP90, P90
|
|
Specificity
|
Detects ~90kDa. Species cross-reactivity: Human, Mouse, Rat, Bovine, Chicken, Dog, Guinea Pig, Hamster, Pig, Monkey, Rabbit, Sheep, Xenopus.
|
|
Application Notes
|
WB 1:5000-10000 (ECL) IP 1:100 (9)
|
|
Purification
|
Antiserum
|
|
Storage
|
-20 °C
|
|
Storage Shipping Temp Max
|
Blue Ice or 4 °C
|
|
Research Area
|
Cell Signaling, Organelles
|
|
Restrictions
|
For Research Use only
|
Alternatives for antigen "Calnexin (N-Term)", type "Antibodies"
|
Hosts
|
Rabbit (1)
|
|
Reactivities
|
Chicken (1), Cow (Bovine) (1), Dog (Canine) (1), Guinea Pig (1), Hamster (1), Human (1), Monkey (1), Mouse (Murine) (1), Pig (Porcine) (1), Rabbit (1), Sheep (Ovine) (1), Xenopus laevis (1)
|
|
Applications
|
Immunocytochemistry (ICC) (1), Immunoprecipitation (IP) (1), Western Blotting (WB) (1)
|
