Heat Shock Protein Cognate 4 (HSC70-4) (pan) antibody

Details for Product No. ABIN361868
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Antigen
Synonyms
BAP74, CG4264, Dmel\\CG4264, E(csp)1545, E(nd)195, HSC-70, HSC4, HSC70, HSC70-4, Hsc-4, Hsc4, Hsc4p, Hsc70, Hsp-c4, Hsp70, anon-WO0118547.237, bs17d06.y1, dhsc70, hsc4, hsc70, hsc70-4, hsp70, i190, l( ... show more
BAP74, CG4264, Dmel\\CG4264, E(csp)1545, E(nd)195, HSC-70, HSC4, HSC70, HSC70-4, Hsc-4, Hsc4, Hsc4p, Hsc70, Hsp-c4, Hsp70, anon-WO0118547.237, bs17d06.y1, dhsc70, hsc4, hsc70, hsc70-4, hsp70, i190, l(3)03550, l(3)L3929, l(3)j7A4, scd show less
Epitope
pan
(1), (1)
Reactivity
Please enquire
(11), (11), (10), (10), (9), (9), (8), (8), (7), (7), (7), (7), (7), (6), (5), (5), (5), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(14), (4)
Clonality
Polyclonal
Application
Western Blotting (WB)
(18), (10), (6), (6), (5), (4), (4)
Pubmed 5 references available
Catalog no. ABIN361868
Quantity 100 µg
Price
393.80 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen The target peptide is a sequence conserved in all known Hsp70 and Hsc70 proteins.
Specificity Detects approx. 70 kDa.
Purification Affinity Purified
Alternative Name Hsp70/Hsc70
Background Synonyms:
Hsc54, Hsc71, Hsc73, Hsp71, Hsp73, HspA10, HspA8, LAP1, NIP71, Hsc70
Hsp70 genes encode abundant heat-inducible 70 kDa hsps (hsp70s). In most eukaryotes hsp70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O % identity. The N-terminal two thirds of hsp70s are more conserved than the C-terminal third. Hsp70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteinsand synthetic peptides. When hsc70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half. The structure of this ATPbinding domain displays multiple features of nucleotide binding proteins.When cells are subjected to metabolic stress (e.g., heat shock) a member of the hsp 70 family, hsp 70 (hsp72), is expressed, hsp 70 is highly related to hsc70 (>90 % sequence identity). Constitutively expressed hsc70 rapidly forms a stable complex with the highly inducible hsp70 in cells following heat shock. The interaction of hsc70 with hsp 70 is regulated by ATP. These two heat shock proteins move together in the cell experiencing stress. Furthermore, research on hsc70 has implicates it with a role in facilitating the recovery of centrosomal structure and function after heat shock.
Research Area Heat Shock Proteins
Application Notes Recommended Dilution: 1:1000 (WB)
Restrictions For Research Use only
Format Lyophilized
Buffer PBS pH 7.4, lyophilized
Storage -20 °C
Background publications Bork, Sander, Valencia: "An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7290-4, 1992 (PubMed).

DeLuca-Flaherty, McKay, Parham et al.: "Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis." in: Cell, Vol. 62, Issue 5, pp. 875-87, 1990 (PubMed).

Rothman: "Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells." in: Cell, Vol. 59, Issue 4, pp. 591-601, 1990 (PubMed).

Brown, Hong-Brown, Doxsey et al.: "Molecular chaperones and the centrosome. A role for HSP 73 in centrosomal repair following heat shock treatment." in: The Journal of biological chemistry, Vol. 271, Issue 2, pp. 833-40, 1996 (PubMed).

General Boorstein, Ziegelhoffer, Craig: "Molecular evolution of the HSP70 multigene family." in: Journal of molecular evolution, Vol. 38, Issue 1, pp. 1-17, 1994 (PubMed).

Hosts (14), (4)
Reactivities (11), (11), (10), (10), (9), (9), (8), (8), (7), (7), (7), (7), (7), (6), (5), (5), (5), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Applications (18), (10), (6), (6), (5), (4), (4)
Epitopes (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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