You are viewing an incomplete version of our website. Please click to reload the website as full version.

STAT6 antibody (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced) (pThr645)

Details for Product anti-STAT6 Antibody No. ABIN361972, Supplier: Log in to see
Antigen
  • D12S1644
  • IL-4-STAT
  • STAT6B
  • STAT6C
Alternatives
anti-Human STAT6 antibody for Immunoprecipitation
Epitope
pThr645
81
37
23
13
13
11
10
10
7
6
5
5
5
5
4
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
387
140
102
12
8
7
6
4
2
1
Host
Rabbit
254
160
3
1
Clonality
Polyclonal
Conjugate
This STAT6 antibody is un-conjugated
14
12
12
12
10
9
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
2
1
1
1
Application
Immunohistochemistry (IHC)
308
144
111
52
45
38
33
25
17
15
6
4
2
1
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Immunogen Peptide sequence around phosphorylation site of pThr645 (P-A-T (p) -I-K) derived from Human STAT6. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of STAT6 only when phosphorylated at threonine 645.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name STAT6 (STAT6 Antibody Abstract)
Background Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
Molecular Weight 110 kDa
NCBI Accession NP_003144
UniProt P42226
Research Area Chromatin and Nuclear Signaling, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling
Application Notes Immunohistochemistry: 1:50-1:100
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Nelms, Keegan, Zamorano, Ryan, Paul: "The IL-4 receptor: signaling mechanisms and biologic functions." in: Annual review of immunology, Vol. 17, pp. 701-38, 1999 (PubMed).

Malabarba, Rui, Deutsch, Chung, Kalthoff, Farrar, Kirken: "Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha." in: The Biochemical journal, Vol. 319 ( Pt 3), pp. 865-72, 1996 (PubMed).

Takeda, Tanaka, Shi, Matsumoto, Minami, Kashiwamura, Nakanishi, Yoshida, Kishimoto, Akira: "Essential role of Stat6 in IL-4 signalling." in: Nature, Vol. 380, Issue 6575, pp. 627-30, 1996 (PubMed).

Quelle, Shimoda, Thierfelder, Fischer, Kim, Ruben, Cleveland, Pierce, Keegan, Nelms: "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis." in: Molecular and cellular biology, Vol. 15, Issue 6, pp. 3336-43, 1995 (PubMed).

Hou, Schindler, Henzel, Ho, Brasseur, McKnight: "An interleukin-4-induced transcription factor: IL-4 Stat." in: Science (New York, N.Y.), Vol. 265, Issue 5179, pp. 1701-6, 1994 (PubMed).