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PKC delta antibody (pSer645)

PKCd Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN362384
  • Target See all PKC delta (PKCd) Antibodies
    PKC delta (PKCd) (Protein Kinase C, delta (PKCd))
    Binding Specificity
    • 22
    • 20
    • 19
    • 16
    • 15
    • 15
    • 15
    • 15
    • 11
    • 8
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer645
    Reactivity
    • 208
    • 152
    • 150
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 219
    • 9
    Rabbit
    Clonality
    • 208
    • 20
    Polyclonal
    Conjugate
    • 92
    • 15
    • 13
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    This PKC delta antibody is un-conjugated
    Application
    • 163
    • 91
    • 81
    • 80
    • 49
    • 46
    • 36
    • 23
    • 20
    • 13
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    The antibody detects endogenous level of PKCd only when phosphorylated at serine 645.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    Peptide sequence around phosphorylation site of pSer645 (R-L-S (p) -Y-S) derived from Human PKCd. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotype
    IgG
    Top Product
    Discover our top product PKCd Primary Antibody
  • Application Notes
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Uenoyama, Ogata, Nakanishi, Kanazawa, Hiroi, Tominaga, Seo, Matsui, Kawai, Suzuki: "Protein kinase C mRNA and protein expressions in hypobaric hypoxia-induced cardiac hypertrophy in rats." in: Acta physiologica (Oxford, England), Vol. 198, Issue 4, pp. 431-40, (2010) (PubMed).

  • Target
    PKC delta (PKCd) (Protein Kinase C, delta (PKCd))
    Alternative Name
    PKCdelta (PKCd Products)
    Synonyms
    MAY1 antibody, PKCD antibody, nPKC-delta antibody, AI385711 antibody, D14Ertd420e antibody, PKC[d] antibody, PKCdelta antibody, Pkcd antibody, fb09d10 antibody, fv43b11 antibody, prkcd antibody, wu:fb09d10 antibody, wu:fv43b11 antibody, zgc:56558 antibody, PKC-delta antibody, may1 antibody, npkc-delta antibody, pkc-delta2 antibody, pkcd antibody, tpa-1 antibody, protein kinase C delta antibody, protein kinase C, delta antibody, protein kinase C, delta a antibody, protein kinase C delta L homeolog antibody, PRKCD antibody, Prkcd antibody, prkcda antibody, prkcd.L antibody, prkcd antibody
    Background
    This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin.
    Molecular Weight
    78 kDa
    NCBI Accession
    NP_006245
    UniProt
    Q05655
    Pathways
    Interferon-gamma Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Dicarboxylic Acid Transport, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, Lipid Metabolism
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