NF-kappaB p100/p52 (AA 864-868) antibody

Details for Product No. ABIN362509
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Antigen
Epitope
AA 864-868
(9), (4), (4), (4), (2), (2), (2), (2), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(40), (40), (35)
Host
Rabbit
(40)
Clonality
Polyclonal
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(40), (39), (18), (14), (12)
Pubmed 5 references available
Quantity 50 µL
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Catalog No. ABIN362509
165.00 $
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Immunogen Peptide sequence around AA 864-868 (E-D-S-A-Y) derived from Human NFkB-p100, p52. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total NFkB-p100/p52 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
Alternative Name NFkappaB-p100/p52
Background NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.
Molecular Weight 120 kDa
NCBI Accession NP_001070
UniProt Q00653
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Haskill, Beg, Tompkins et al.: "Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity." in: Cell, Vol. 65, Issue 7, pp. 1281-9, 1991 (PubMed).

Baeuerle, Henkel: "Function and activation of NF-kappa B in the immune system." in: Annual review of immunology, Vol. 12, pp. 141-79, 1994 (PubMed).

Baeuerle, Baltimore: "NF-kappa B: ten years after." in: Cell, Vol. 87, Issue 1, pp. 13-20, 1996 (PubMed).

Xiao, Harhaj, Sun: "NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100." in: Molecular cell, Vol. 7, Issue 2, pp. 401-9, 2001 (PubMed).

Qu, Qing, Rabson et al.: "Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 44563-72, 2004 (PubMed).

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