You are viewing an incomplete version of our website. Please click to reload the website as full version.

STAT3 antibody (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)) (AA 725-729)

Details for Product anti-STAT3 Antibody No. ABIN362568, Supplier: Login to see
Antigen
  • 1110034C02Rik
  • AW109958
  • Aprf
  • APRF
  • HIES
  • Xstat3
  • aprf
  • hies
  • stat3
  • wu:fc15d02
  • wu:fl59g06
  • z-Stat3
Alternatives
anti-Human STAT3 antibody for Western Blotting
Epitope
AA 725-729
111
95
88
30
22
17
16
16
15
14
13
8
6
5
5
5
5
4
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
544
255
197
31
24
24
13
11
10
5
5
4
3
2
2
2
2
1
1
1
1
Host
Rabbit
470
103
36
4
2
1
Clonality
Polyclonal
Conjugate
This STAT3 antibody is un-conjugated
24
22
18
13
12
11
7
4
3
2
2
2
2
2
2
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
508
240
220
85
77
77
56
25
24
13
13
12
9
7
3
3
2
2
2
1
1
1
1
1
Supplier
Login to see
Supplier Product No.
Login to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Immunogen Peptide sequence around AA 725-729 (P-M-S-P-R) derived from Human STAT3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total STAT3 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name STAT3 (STAT3 Antibody Abstract)
Background Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.
Molecular Weight 88 kDa
NCBI Accession NP_003141
UniProt P40763
Research Area Embryogenesis, Embryonic stem cells, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Product cited in: Cheng, Wang, Xia et al.: "A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation." in: EMBO molecular medicine, Vol. 4, Issue 10, pp. 1112-25, 2012 (PubMed).

Yu, Qin, He et al.: "Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling." in: Hepatology (Baltimore, Md.), Vol. 54, Issue 3, pp. 979-88, 2011 (PubMed).

Background publications Bromberg, Wrzeszczynska, Devgan et al.: "Stat3 as an oncogene." in: Cell, Vol. 98, Issue 3, pp. 295-303, 1999 (PubMed).

Heim: "The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus." in: Journal of receptor and signal transduction research, Vol. 19, Issue 1-4, pp. 75-120, 1999 (PubMed).

Catlett-Falcone, Landowski, Oshiro et al.: "Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells." in: Immunity, Vol. 10, Issue 1, pp. 105-15, 1999 (PubMed).

Garcia, Jove: "Activation of STAT transcription factors in oncogenic tyrosine kinase signaling." in: Journal of biomedical science, Vol. 5, Issue 2, pp. 79-85, 1998 (PubMed).

Takeda, Noguchi, Shi et al.: "Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 8, pp. 3801-4, 1997 (PubMed).