You are viewing an incomplete version of our website. Please click to reload the website as full version.

APP antibody (Amyloid beta (A4) Precursor Protein) (AA 666-670)

Details for Product anti-APP Antibody No. ABIN362850, Supplier: Log in to see
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
Alternatives
anti-Human APP antibody for Enzyme Immunoassay
Epitope
AA 666-670
117
108
51
35
25
18
17
17
15
15
14
14
14
13
12
11
10
8
8
7
6
6
6
5
5
5
5
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
802
306
276
40
11
11
8
8
6
3
2
2
1
1
1
1
Host
Rabbit
565
217
46
4
2
Clonality
Polyclonal
Conjugate
This APP antibody is un-conjugated
47
36
34
17
13
13
13
13
13
13
13
12
12
11
11
1
Application
Immunofluorescence (IF), Western Blotting (WB)
542
311
228
146
132
73
52
26
23
18
15
10
9
8
6
3
2
2
2
2
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Immunogen Peptide sequence around AA 666-670 (A-V-T-P-E ) derived from Human APP. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total APP protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
Alternative Name APP (APP Antibody Abstract)
Background APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Molecular Weight 100-140 kDa
NCBI Accession NP_000475
UniProt P05067
Research Area Signaling
Pathways Caspase Cascade in Apoptosis, EGFR Signaling Pathway
Application Notes Western blotting: 1:500-1:1000
Immunofluorescence: 1:100-1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Iijima, Ando, Takeda et al.: "Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5." in: Journal of neurochemistry, Vol. 75, Issue 3, pp. 1085-91, 2000 (PubMed).

Eng, Lund, Campenot: "Synthesis of beta-tubulin, actin, and other proteins in axons of sympathetic neurons in compartmented cultures." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 1, pp. 1-9, 1999 (PubMed).

Hung, Selkoe: "Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein." in: The EMBO journal, Vol. 13, Issue 3, pp. 534-42, 1994 (PubMed).

Suzuki, Oishi, Marshak et al.: "Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein." in: The EMBO journal, Vol. 13, Issue 5, pp. 1114-22, 1994 (PubMed).