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Histone Deacetylase 4 (HDAC4) (AA 244-248) antibody

Details for Product No. ABIN363088, Supplier: Login to see
Antigen
  • CG1770
  • DHDAC4
  • Dmel\\CG1770
  • GC1770
  • HDAC
  • HDAC4a
  • dHDAC4
  • dmHDA405
  • hdac4
  • dana_GLEANR_19966
  • DanaGF18710
  • GF18710
  • HDAC4
  • AHO3
  • BDMR
  • HA6116
  • HD4
  • HDAC-4
  • HDAC-A
  • HDACA
  • 4932408F19Rik
  • AI047285
  • wu:fa96d08
  • wu:fc56f08
  • zgc:152701
Epitope
AA 244-248
47
34
20
15
10
10
6
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
259
101
71
8
3
3
2
2
1
1
1
1
1
Host
Rabbit
226
39
2
Clonality
Polyclonal
Conjugate
Un-conjugated
10
9
9
4
4
4
3
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
235
85
49
31
30
22
13
12
11
5
3
1
1
1
1
Supplier
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Immunogen Peptide sequence around AA 244-248, 257-261, 218-222 (T-A-S-E-P) derived from Human HDAC4, HDAC5, HDAC9. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total HDAC4/HDAC5/HDAC9 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen. Specificity/Sensitivity HDAC4/HDAC5/HDAC9 (Ab-246/259/220) Antibody detects endogenous levels of total HDAC4/HDAC5/HDAC9 protein.
Alternative Name HDAC4/HDAC5/HDAC9 (HDAC4 Antibody Abstract)
Background Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
Molecular Weight 124 kDa
NCBI Accession NP_055522, NP_001015
UniProt Q9UKV0
Pathways
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Vigushin, Coombes: "Targeted histone deacetylase inhibition for cancer therapy." in: Current cancer drug targets, Vol. 4, Issue 2, pp. 205-18, 2004 (PubMed).

Thiagalingam, Cheng, Lee et al.: "Histone deacetylases: unique players in shaping the epigenetic histone code." in: Annals of the New York Academy of Sciences, Vol. 983, pp. 84-100, 2003 (PubMed).

Marmorstein: "Structure and function of histone acetyltransferases." in: Cellular and molecular life sciences : CMLS, Vol. 58, Issue 5-6, pp. 693-703, 2001 (PubMed).

Cress, Seto: "Histone deacetylases, transcriptional control, and cancer." in: Journal of cellular physiology, Vol. 184, Issue 1, pp. 1-16, 2000 (PubMed).