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CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (AA 698-702)

Details for Product anti-CBL Antibody No. ABIN363123, Supplier: Log in to see
Antigen
  • 4732447J05Rik
  • C-CBL
  • c-Cbl
  • c-cbl-like
  • cbl
  • Cbl-2
  • CBL2
  • FRA11B
  • NSLL
  • RGD1561386
  • RNF55
Alternatives
anti-Human CBL antibody for Western Blotting
Epitope
AA 698-702
46
40
26
23
17
5
5
4
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
250
135
129
6
4
4
4
1
1
1
Host
Rabbit
202
36
16
1
Clonality
Polyclonal
Conjugate
This CBL antibody is un-conjugated
7
7
7
7
6
5
5
5
5
5
5
5
4
2
2
Application
Immunohistochemistry (IHC)
169
71
67
55
55
32
18
17
6
5
4
3
3
1
1
1
1
1
Supplier
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Immunogen Peptide sequence around AA 698-702 (T-E-Y-M-T) derived from Human c-Cbl. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total c-Cbl protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen .
Alternative Name c-Cbl (CBL Antibody Abstract)
Background Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
Molecular Weight 120 kDa
UniProt P22681
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Owen-Schaub, Chan, Cusack, Roth, Hill: "Fas and Fas ligand interactions in malignant disease." in: International journal of oncology, Vol. 17, Issue 1, pp. 5-12, 2000 (PubMed).

Chen, Cizeau, Vande Velde, Park, Bozek, Bolton, Shi, Dubik, Greenberg: "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins." in: The Journal of biological chemistry, Vol. 274, Issue 1, pp. 7-10, 1999 (PubMed).

Thien, Langdon: "c-Cbl: a regulator of T cell receptor-mediated signalling." in: Immunology and cell biology, Vol. 76, Issue 5, pp. 473-82, 1999 (PubMed).

Drivas, Shih, Coutavas, DEustachio, Rush: "Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3." in: Oncogene, Vol. 6, Issue 1, pp. 3-9, 1991 (PubMed).