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IL1R1 antibody (Extracellular Domain)

IL1R1 Reactivity: Human ELISA, IHC, IHC (p), RIA Host: Mouse Monoclonal 40101 unconjugated
Catalog No. ABIN364253
  • Target See all IL1R1 Antibodies
    IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))
    Binding Specificity
    • 28
    • 17
    • 16
    • 8
    • 8
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reactivity
    • 119
    • 63
    • 53
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 113
    • 13
    • 9
    • 2
    • 1
    • 1
    Mouse
    Clonality
    • 120
    • 19
    Monoclonal
    Conjugate
    • 59
    • 16
    • 11
    • 8
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    This IL1R1 antibody is un-conjugated
    Application
    • 122
    • 64
    • 45
    • 39
    • 15
    • 15
    • 13
    • 13
    • 11
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Radioimmunoassay (RIA)
    Brand
    IHC-plus™
    Specificity
    These antibodies react with cell surface and soluble human IL-1 receptor, Specific epitopes are unknown, but they do partially inhibit (30-50 % ) binding of one another to IL-1 receptor. They do not block binding of IL-1 to receptor, and they do not cross-react with receptors for human IL-2 or IL-4.
    Purification
    Protein G purified
    Immunogen
    The extracellular domain of the type I human IL-1 receptor.

    Type of Immunogen: Protein
    Clone
    40101
    Isotype
    IgG2b
    Top Product
    Discover our top product IL1R1 Primary Antibody
  • Application Notes
    Approved: ELISA, IHC, IHC-P (10 μg/mL), RIA

    Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in  pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 10 μg/mL. ELISA: Can be used as capture reagents or second antibody at a concentration of 5 μg/mL. RIA: Concentrations of 20-30 ng/mL of these antibodies will bind radiolabeled IL-1 receptor in a radioimmunoassay format. Immunocytochemistry: IL-1 receptor can be detected on cultured cells using antibody concentrations of 10-100 μg/mL.

    Not recommended for: WB
    Comment

    Target Species of Antibody: Human

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    PBS,  pH 7.4. Sourced in Ascites.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Short term: -20°C
    Long term: -70°C
    Avoid freeze-thaw cycles.
  • Target
    IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))
    Alternative Name
    IL1RA / IL1R1 (IL1R1 Products)
    Synonyms
    CD121A antibody, D2S1473 antibody, IL-1R-alpha antibody, IL1R antibody, IL1RA antibody, P80 antibody, CD121a antibody, CD121b antibody, IL-iR antibody, Il1r-1 antibody, DER4 antibody, Fit-1 antibody, Ly84 antibody, ST2L antibody, St2 antibody, St2-rs1 antibody, T1 antibody, T1/ST2 antibody, interleukin 1 receptor type 1 antibody, interleukin 1 receptor, type I antibody, interleukin 1 receptor-like 1 antibody, IL1R1 antibody, Il1r1 antibody, Il1rl1 antibody
    Background
    Name/Gene ID: IL1R1
    Family: Interleukin

    Synonyms: IL1R1, Antigen CD121a, D2S1473, IL-1R-1, IL-1R-alpha, IL-1RT-1, IL-1RT1, IL1R, IL1RA, IL1RT1, Interleukin receptor 1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, CD121A, CD121a antigen, Interleukin 1 receptor, type I, Interleukin-1 receptor type I, Interleukin-1 type i receptor, p80
    Gene ID
    3554
    UniProt
    P14778
    Pathways
    NF-kappaB Signaling, Carbohydrate Homeostasis, Cancer Immune Checkpoints
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