Relaxin 3 Receptor 1 (RXFP3) antibody

Antigen: Relaxin 3 Receptor 1 (RXFP3)

Synonyms: SALPR, RLN3R1, RXFPR3, GPCR135, MGC141998, MGC142000, Salpr, Rln3r1, RGD1311550

Clonality: Monoclonal (2H10)

Host: Mouse

Reactivity: Human, Rat (Rattus)

Application: ELISA, Immunohistochemistry (IHC)

Catalog no.: ABIN368640

Additional Information

Alternative name: RXFP3

Gene ID: 51289

Immunogen: Partial peptide of Human RXFP3 (3rd extracellular domain)

Format: Affinity-purified

Isotype: IgG2b kappa  (Matching secondary antibodies)

Clone: 2H10

Description: Function: Receptor for relaxin-3. Binding of the ligand inhibit cAMP accumulation. Subcellular location: Cell membrane, Multi-pass membrane protein. Tissue specificity: Expressedpredominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis. Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Application Details

Application Notes: Recommended dilutions: ELISA - 1ug/ml, IHC - 10ug/ml

Concentration: 0.25 mg/ml

Purification: ProteinG Affinity Purified

Buffer: PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]

Storage: Store below -20°C

Research Area: Signaling

Restrictions: For Research Use only

Images

Rat cerebellum tissue

Publications

Publications: Matsumoto, Kamohara, Sugimoto et al.: "The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors." in: Gene, Vol. 248, Issue 1-2, pp. 183-9, 2000 (PubMed).

Liu, Chen, Sutton et al.: "Identification of relaxin-3/INSL7 as a ligand for GPCR142." in: The Journal of biological chemistry, Vol. 278, Issue 50, pp. 50765-70, 2003 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).