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CD22 antibody (PE)

CD22 Reactivity: Mouse FACS Host: Rat Monoclonal 2D6 PE
Catalog No. ABIN370869
  • Target See all CD22 Antibodies
    CD22 (CD22 Molecule (CD22))
    Reactivity
    • 150
    • 48
    • 24
    • 5
    • 3
    • 2
    • 2
    • 1
    Mouse
    Host
    • 97
    • 62
    • 13
    Rat
    Clonality
    • 120
    • 54
    Monoclonal
    Conjugate
    • 81
    • 14
    • 12
    • 10
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD22 antibody is conjugated to PE
    Application
    • 109
    • 69
    • 45
    • 38
    • 37
    • 17
    • 12
    • 11
    • 11
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificity
    This antibody is specific to CD22 (Mr 150 kDa), a B Lymphocyte Adhesion Molecule.
    Characteristics
    Synonyms: SIGLEC2, Siglec-2, B-cell receptor CD22, Leu-14, BL-CAM, Sialic acid-binding Ig-like lectin 2,B-lymphocyte cell adhesion molecule
    Clone
    2D6
    Isotype
    IgG1
    Top Product
    Discover our top product CD22 Primary Antibody
  • Application Notes
    Flow Cytometry: < / = 0.2 μg/10^6 cells. (Ref.2)
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS containing 0.09 % Sodium Azide as preservative and a stabilizing agent.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    CD22 (CD22 Molecule (CD22))
    Alternative Name
    CD22 (CD22 Products)
    Synonyms
    A530093D23 antibody, Lyb-8 antibody, Lyb8 antibody, SIGLEC-2 antibody, SIGLEC2 antibody, siglec-2 antibody, CD22 antigen antibody, CD22 molecule antibody, Cd22 antibody, CD22 antibody
    Background
    CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. (Ref.1,2) CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. (Ref.2-4) Its intracellular domain is phosphorylated after antigen receptor crosslinking and is involved in negative regulation of B-cell activation. (Ref.6-9)Synonyms: B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Leu-14, SIGLEC2, Sialic acid-binding Ig-like lectin 2, Siglec-2
    Gene ID
    12483
    UniProt
    P35329
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