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T-Cell Receptor gamma/delta antibody (FITC)

Details for Product No. ABIN371049, Supplier: Login to see New
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Mouse (Murine)
(106), (47), (33), (16), (2)
(103), (96), (6)
Clonality (Clone)
Monoclonal ()
(44), (44), (22), (10), (4), (4), (4), (4), (3), (2)
Flow Cytometry (FACS)
(181), (67), (40), (37), (14), (9), (8), (8), (6), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 7 references available
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Quantity 0.5 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Clone UC7-13D5
Isotype IgG
Characteristics Synonyms: TCRG, TCRD, T-Cell Receptor gamma, T-Cell Receptor delta, T-Cell Receptor gamma delta
Alternative Name T Cell Receptor / TCR gamma/delta
Background T cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment, a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. The TCR gamma/delta heterodimer of the CD3/T-cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. (Ref.1) It is expressed during thymopoiesis and on the small subpopulation of gamma/delta TCR expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are gamma/delta+ and have limited receptor diversity. (Ref.1,2) The TCR gamma/delta heterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signal transduction mediated by the invariant chains leads to T cell activation. (Ref.3)Synonyms: T-Cell Receptor delta, T-Cell Receptor gamma, T-Cell Receptor gamma delta, TCRD, TCRG
Research Area Immunology, Receptors, Signaling
Application Notes Flow Cytometry: < / = 1 μg/10^6 cells. (Ref.4-7)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Houlden, Matis, Cron et al.: "A TCR gamma delta cell recognizing a novel TL-encoded gene product." in: Cold Spring Harbor symposia on quantitative biology, Vol. 54 Pt 1, pp. 45-55, 1990 (PubMed).

Davis: "T cell receptor gene diversity and selection." in: Annual review of biochemistry, Vol. 59, pp. 475-96, 1990 (PubMed).

Dent, Matis, Hooshmand et al.: "Self-reactive gamma delta T cells are eliminated in the thymus." in: Nature, Vol. 343, Issue 6260, pp. 714-9, 1990 (PubMed).

Klausner, Samelson: "T cell antigen receptor activation pathways: the tyrosine kinase connection." in: Cell, Vol. 64, Issue 5, pp. 875-8, 1991 (PubMed).

Barrett, Hedrick, Dent et al.: "Control of self-reactivity in the intestine." in: Immunologic research, Vol. 10, Issue 3-4, pp. 341-8, 1992 (PubMed).

Allison, Havran: "The immunobiology of T cells with invariant gamma delta antigen receptors." in: Annual review of immunology, Vol. 9, pp. 679-705, 1991 (PubMed).

Bluestone, Cron, Barrett et al.: "Repertoire development and ligand specificity of murine TCR gamma delta cells." in: Immunological reviews, Vol. 120, pp. 5-33, 1991 (PubMed).

Catalog No. ABIN371049
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