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TCR gamma/delta antibody

TCR gamma/delta Reactivity: Mouse FACS, IP, IHC (fro), Func Host: Hamster Monoclonal UC7-13D5 unconjugated
Catalog No. ABIN371050
  • Target See all TCR gamma/delta products
    TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))
    Reactivity
    • 22
    • 18
    • 8
    • 8
    • 5
    • 4
    Mouse
    Host
    • 34
    • 12
    • 11
    • 2
    Hamster
    Clonality
    • 59
    Monoclonal
    Conjugate
    • 18
    • 13
    • 10
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TCR gamma/delta antibody is un-conjugated
    Application
    • 59
    • 16
    • 15
    • 10
    • 10
    • 3
    • 3
    • 2
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
    Characteristics
    Synonyms: TCRG, TCRD, T-Cell Receptor gamma, T-Cell Receptor delta, T-Cell Receptor gamma delta
    Endotoxin Level
    Low Endotoxin
    Clone
    UC7-13D5
    Isotype
    IgG
  • Application Notes
    Flow Cytometry. (Ref.4-7)Immunoprecipitation. (Ref.5)Immunohistochemistry on Frozen Sections. (Ref.8)In vitro Activation of gamma-delta TCR-bearing cells. (Ref.5)In vivo Depletion of gamma-delta TCR-expressing T cells. (Ref.5)
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    PBS containing no preservatives.
    Preservative
    Without preservative
    Storage
    -20 °C
    Storage Comment
    Store the antibody undiluted (in aliquous) at -20 °C. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))
    Alternative Name
    T Cell Receptor / TCR gamma/delta (TCR gamma/delta Products)
    Background
    T cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment, a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. The TCR gamma/delta heterodimer of the CD3/T-cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. (Ref.1) It is expressed during thymopoiesis and on the small subpopulation of gamma/delta TCR expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are gamma/delta+ and have limited receptor diversity. (Ref.1,2) The TCR gamma/delta heterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signal transduction mediated by the invariant chains leads to T cell activation. (Ref.3)Synonyms: T-Cell Receptor delta, T-Cell Receptor gamma, T-Cell Receptor gamma delta, TCRD, TCRG
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