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CTLA4 antibody (Cytotoxic T-Lymphocyte-Associated Protein 4) (FITC)

Details for Product anti-CTLA4 Antibody No. ABIN371056, Supplier: Log in to see
Antigen
  • CD
  • Cd152
  • CD152
  • CELIAC3
  • CTLA-4
  • Ctla-4
  • CTLA4
  • GRD4
  • GSE
  • IDDM12
  • Ly-56
  • sCTLA4
Reactivity
Mouse (Murine)
226
212
85
19
7
2
2
Host
Hamster
222
89
76
32
25
6
Clonality (Clone)
Monoclonal ()
Conjugate
This CTLA4 antibody is conjugated to FITC
60
37
36
15
7
7
7
7
6
6
6
5
5
5
5
5
5
5
3
3
3
2
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
301
187
171
64
62
61
49
22
22
20
16
7
6
5
4
4
4
4
3
2
2
2
2
1
1
1
Supplier
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Clone 1B8
Isotype IgG
Specificity This Monoclonal antibody is specific to CD152/CTLA-4.
Characteristics Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
Alternative Name CD152 / CTLA4 (CTLA4 Antibody Abstract)
Background The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the co-stimulatory molecule CD28, and both molecules share common B7 family counter-receptors. (Ref.1-4) However CD152 is thought to be a negative regulator of T cell activation (Ref.1-3) and may play a role in apoptotic control of T cells. CD152 exists as a 69 kDa homodimer (Ref.1), and is relatively conserved among Humans, Mice and Chickens. (Ref.2)Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
Gene ID 100505288
UniProt P09793
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: < / = 3 μg/10^6 cells. (Ref.1,2)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CTLA4 antibody (Cytotoxic T-Lymphocyte-Associated Protein 4)  (FITC) (ABIN371056) anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) antibody (FITC)
Background publications Perkins, Wang, Donovan, He, Mark, Guan, Wang, Walunas, Bluestone, Listman, Finn: "Regulation of CTLA-4 expression during T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 11, pp. 4154-9, 1996 (PubMed).

Leach, Krummel, Allison: "Enhancement of antitumor immunity by CTLA-4 blockade." in: Science (New York, N.Y.), Vol. 271, Issue 5256, pp. 1734-6, 1996 (PubMed).

Walunas, Lenschow, Bakker, Linsley, Freeman, Green, Thompson, Bluestone: "CTLA-4 can function as a negative regulator of T cell activation." in: Immunity, Vol. 1, Issue 5, pp. 405-13, 1995 (PubMed).

Freeman, Lombard, Gimmi, Brod, Lee, Laning, Hafler, Dorf, Gray, Reiser: "CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 12, pp. 3795-801, 1993 (PubMed).