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Integrin beta 7 antibody (ITGB7) (PE)

Details for Product anti-ITGB7 Antibody No. ABIN371136, Supplier: Log in to see
Antigen
  • Ly69
  • integrin beta 7
  • integrin, beta 7
  • Itgb7
  • ITGB7
Reactivity
Mouse (Murine)
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16
15
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Host
Rat
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5
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2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 7 antibody is conjugated to PE
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12
8
5
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4
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3
3
3
2
2
2
2
2
2
2
2
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Application
Flow Cytometry (FACS)
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26
14
13
6
6
3
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2
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2
1
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Options
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Immunogen AKR/Cum mouse spontaneous T lymphoma cell line TK1. (Ref. 1)
Clone DATK32
Isotype IgG2a
Specificity This antibody is specific to mouse LPAM1 (Integrin alpha 4 beta 7). It recognises a conformational epitope on the heterodimer.
Characteristics Synonyms: Integrin beta-P, M290 IEL antigen, ITGB7, LPAM-1, LPAM1, Lymphocyte Peyer PatchAdhesion Molecule
Alternative Name Integrin beta-7 (ITGB7 Antibody Abstract)
Background The lymphocyte Peyer's patch adhesion molecule (LPAM-1), also known as Integrin alpha 4 beta 7 is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. (Ref.1-4) The Monoclonal antibody DATK32 has been shown to be useful for studies of the induction of homotypic cellular aggregation and the blockade of binding to cell adhesion molecules. (Ref.1)Synonyms: Adhesion Molecule, ITGB7, Integrin beta-P, LPAM-1, LPAM1, Lymphocyte Peyer Patch, M290 IEL antigen
Gene ID 16421
UniProt P26011
Application Notes Flow Cytometry: < / = 0.1 μg/10^6 cells. (Ref.1-4)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative and a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Andrew, Rott, Kilshaw, Butcher: "Distribution of alpha 4 beta 7 and alpha E beta 7 integrins on thymocytes, intestinal epithelial lymphocytes and peripheral lymphocytes." in: European journal of immunology, Vol. 26, Issue 4, pp. 897-905, 1996 (PubMed).

Andrew, Berlin, Honda, Yoshino, Hamann, Holzmann, Kilshaw, Butcher: "Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 9, pp. 3847-61, 1994 (PubMed).

Hamann, Andrew, Jablonski-Westrich, Holzmann, Butcher: "Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 7, pp. 3282-93, 1994 (PubMed).

Berlin, Berg, Briskin, Andrew, Kilshaw, Holzmann, Weissman, Hamann, Butcher: "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1." in: Cell, Vol. 74, Issue 1, pp. 185-95, 1993 (PubMed).