LAMP1 antibody (Lysosomal-Associated Membrane Protein 1) (FITC)

Details for Product anti-LAMP1 Antibody No. ABIN371198, Supplier: Log in to see
Antigen
  • AI196048
  • CD107a
  • Lamp-1
  • LAMPA
  • LGP120
  • LEP100
  • lysosomal-associated membrane protein 1
  • lysosome-associated membrane glycoprotein 1
  • lysosome-associated membrane glycoprotein 1-like
  • Lamp1
  • LAMP1
  • LAMP-1
  • LOC100772093
Alternatives
anti-Mouse (Murine) LAMP1 antibody for Cytometry by Time of Flight
Reactivity
Mouse (Murine)
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Host
Rat
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1
Clonality (Clone)
Monoclonal ()
Conjugate
This LAMP1 antibody is conjugated to FITC
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37
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15
13
9
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Application
Flow Cytometry (FACS)
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Options
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Immunogen Plasma membrane fraction of mouse embryo NIH3T3 cell line. (Ref. 1)
Clone 1D4B
Isotype IgG2a
Specificity This antibody is specific to CD107a/LAMP-1 (Mr 110-140 kDa with a core protein of Mr ~40 kDa).
Characteristics Synonyms: LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1, CD107Antigen-like Family Member A
Alternative Name CD107a / LAMP1 (LAMP1 Antibody Abstract)
Background CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes one of the two major sialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomes from other organelles. (Ref.1) It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. (Ref.2) CD107a is principally expressed in epithelial cells and macrophages in a variety of organs in normal and Beige mutant mice. (Ref.3) LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. (Ref.4)Synonyms: CD107 Antigen-like Family Member A, LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1
Gene ID 16783
UniProt P11438
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Autophagy
Application Notes Flow Cytometry: < / = 1 μg/10^6 cells. (Ref.5)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Rohrer, Schweizer, Russell, Kornfeld: "The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane." in: The Journal of cell biology, Vol. 132, Issue 4, pp. 565-76, 1996 (PubMed).

Fukuda: "Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking." in: The Journal of biological chemistry, Vol. 266, Issue 32, pp. 21327-30, 1991 (PubMed).