CD16 Molecule (CD16) antibody (Biotin)

Details for Product No. ABIN371542, Supplier: Log in to see
Antigen
  • Fcgr3
  • Fcgr3a
  • CD16
  • FCGR3
  • FCGR3@
  • CD16b
  • FCG3
  • FCR-10
  • FCRIII
  • FCRIIIb
  • FcRIII
  • Fc fragment of IgG, low affinity IIa, receptor
  • Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
  • Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
  • Fc receptor, IgG, low affinity III
  • Fc-gamma RIII
  • Fcgr2a
  • FCGR3A
  • FCGR3B
  • Fcgr3
  • FCGR3
Alternatives
anti-Human CD16 Molecule antibody for Biochemical Assay
Reactivity
Human
410
61
22
20
16
14
8
6
4
4
4
3
3
2
2
Host
Mouse
403
43
31
1
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
75
66
42
20
16
8
7
6
5
5
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
424
99
67
52
49
39
38
23
15
10
6
5
5
4
4
4
2
2
2
2
1
1
1
1
1
1
Options
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Clone GRM1
Isotype IgG2a
Specificity This antibody recognizes CD16/FcgammaRIII.
Characteristics Synonyms: CD16a, CD16b, FCG3, FCGR3, IGFR3, FCGR3B, Fc-gamma RIII, FcRIII, Low affinityimmunoglobulin gamma Fc region receptor III
Alternative Name CD16 (CD16 Antibody Abstract)
Background CD16 (FcgammaRIII) serves as a low affinity IgG receptor. Human CD16 is expressed in two forms CD16a and CD16b. CD16a is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. CD16b is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype. CD16 is involved in NK activation and signal transduction. (Ref.1-5)Synonyms: CD16A, FCG3, FCGR3, FCGR3A, Fc-gamma RIII, Fc-gamma RIII-alpha, Fc-gamma RIIIa, FcR-10, FcRIII, FcRIIIa, IGFR3, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor III-A
Gene ID 2214
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes Flow Cytometry: 10 μL/10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Takai, Li, Sylvestre, Clynes, Ravetch: "FcR gamma chain deletion results in pleiotrophic effector cell defects." in: Cell, Vol. 76, Issue 3, pp. 519-29, 1994 (PubMed).

Ravetch, Perussia: "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions." in: The Journal of experimental medicine, Vol. 170, Issue 2, pp. 481-97, 1989 (PubMed).