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LAMP1 antibody (Lysosomal-Associated Membrane Protein 1) (PE)

Details for Product anti-LAMP1 Antibody No. ABIN371599, Supplier: Log in to see
Antigen
  • AI196048
  • CD107a
  • Lamp-1
  • LAMPA
  • LGP120
  • LEP100
Reactivity
Human
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123
82
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14
10
5
3
2
Host
Mouse
189
105
57
2
Clonality (Clone)
Monoclonal ()
Conjugate
This LAMP1 antibody is conjugated to PE
32
26
23
13
7
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4
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4
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2
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2
1
1
1
1
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1
1
1
1
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1
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1
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1
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1
Application
Flow Cytometry (FACS)
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168
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46
33
27
19
14
12
4
3
3
2
2
2
1
1
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Supplier
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Clone H4A3
Isotype IgG1
Specificity This antibody recognizes CD107a/LAMP-1.
Characteristics Synonyms: LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1, CD107Antigen-like Family Member A
Alternative Name CD107a / LAMP1 (LAMP1 Antibody Abstract)
Background CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium. (Ref.1-7)Synonyms: CD107 Antigen-like Family Member A, LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1
Gene ID 3916
UniProt P11279
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: 10 μL/10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.09 % Sodium Azide as preservative and a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Sawada, Lowe, Fukuda: "E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels." in: The Journal of biological chemistry, Vol. 268, Issue 17, pp. 12675-81, 1993 (PubMed).

Sawada, Tsuboi, Fukuda: "Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials." in: The Journal of biological chemistry, Vol. 269, Issue 2, pp. 1425-31, 1994 (PubMed).

Chen, Cha, Yuksel et al.: "Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. Sequence similarity to proteins bearing onco-differentiation antigens." in: The Journal of biological chemistry, Vol. 263, Issue 18, pp. 8754-8, 1988 (PubMed).

Febbraio, Silverstein: "Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein." in: The Journal of biological chemistry, Vol. 265, Issue 30, pp. 18531-7, 1990 (PubMed).