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Details for Product No. ABIN371646

Toll-Like Receptor 2 (TLR2) antibody (PE)

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Synonyms TIL4, CD282, Ly105
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Flow Cytometry (FACS)
Pubmed 15 references available
Catalog no. ABIN371646
Quantity 100 tests
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Clone 2B4A1
Isotype IgG2a
Characteristics Synonyms: Toll-like receptor 2
Alternative Name CD282 / TLR2
Background The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteinscharacterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains aconserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRsrecognize specific molecular patterns that are present in microbial components andrespond to these components in order eliminate or limit invading microbes. To date, tenmammalian homologs of TLRs have been described. Activation of TLR2 leads to theinitiation of apoptosis and the activation of the NK-kB pathway by the adaptor moleculeMyD88. TLR2 recognizes and is activated by components from a broad variety ofmicroorganisms including lipoproteins from Gram-negative bacteria, Mycoplasma,spirochetes, peptidoglycan and LTAs from Gram-positive bacteria, lipoarabinomannanfrom mycobacteria, glycoinositolphospholipids, phenolsolublemodulin, zymosan from yeast and neisserial porins. TLR2 has been reported to functionallyassociate with TLR1 and TLR6 in order to recognize various lipopeptides. (Ref. 1-16)
UniProt O60603
Research Area Signaling, Immunology, Inflammation
Application Notes Flow Cytometry: 10 µl/10e6. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 1.0 ml of PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Schwandner, Dziarski, Wesche et al.: "Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2." in: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 17406-9, 1999 (PubMed).

Yoshimura, Lien, Ingalls et al.: "Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 1, pp. 1-5, 1999 (PubMed).

Aliprantis, Yang, Mark et al.: "Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2." in: Science (New York, N.Y.), Vol. 285, Issue 5428, pp. 736-9, 1999 (PubMed).

Hirschfeld, Kirschning, Schwandner et al.: "Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 5, pp. 2382-6, 1999 (PubMed).

Means, Wang, Lien et al.: "Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 7, pp. 3920-7, 1999 (PubMed).

Underhill, Ozinsky, Hajjar et al.: "The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens." in: Nature, Vol. 401, Issue 6755, pp. 811-5, 1999 (PubMed).

Takeuchi, Hoshino, Kawai et al.: "Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components." in: Immunity, Vol. 11, Issue 4, pp. 443-51, 1999 (PubMed).

Lien, Sellati, Yoshimura et al.: "Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products." in: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33419-25, 1999 (PubMed).

Aliprantis, Yang, Weiss et al.: "The apoptotic signaling pathway activated by Toll-like receptor-2." in: The EMBO journal, Vol. 19, Issue 13, pp. 3325-36, 2000 (PubMed).

Wyllie, Kiss-Toth, Visintin et al.: "Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 12, pp. 7125-32, 2000 (PubMed).

Hajjar, OMahony, Ozinsky et al.: "Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 15-9, 2001 (PubMed).

Opitz, Schröder, Spreitzer et al.: "Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation." in: The Journal of biological chemistry, Vol. 276, Issue 25, pp. 22041-7, 2001 (PubMed).

Campos, Almeida, Takeuchi et al.: "Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 416-23, 2001 (PubMed).

Takeuchi, Kawai, Mühlradt et al.: "Discrimination of bacterial lipoproteins by Toll-like receptor 6." in: International immunology, Vol. 13, Issue 7, pp. 933-40, 2001 (PubMed).

Massari, Henneke, Ho et al.: "Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 4, pp. 1533-7, 2002 (PubMed).

Alternatives for antigen "Toll-Like Receptor 2 (TLR2)", type "Antibodies"
Hosts (277), (92), (38), (6), (5)
Reactivities (321), (155), (23), (20), (13), (13), (12), (4), (2), (1), (1), (1)
Applications (245), (158), (97), (94), (57), (49), (47), (44), (31), (28), (26), (10), (6), (2), (2), (1), (1), (1)
Conjugates (54), (52), (30), (6), (5), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (25), (14), (8), (6), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)