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CGRP antibody

CALCA Reactivity: Human, Rat, Mammalian IF, IHC (fro) Host: Mouse Monoclonal 4901 unconjugated
Catalog No. ABIN371823
  • Target See all CGRP (CALCA) Antibodies
    CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))
    Reactivity
    • 66
    • 38
    • 12
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mammalian
    Host
    • 60
    • 17
    • 6
    • 2
    • 2
    • 1
    Mouse
    Clonality
    • 70
    • 17
    Monoclonal
    Conjugate
    • 58
    • 7
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CGRP antibody is un-conjugated
    Application
    • 55
    • 39
    • 29
    • 13
    • 13
    • 11
    • 9
    • 8
    • 8
    • 8
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This antibody is specific for Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP). Suggested Positive Controls: Dorsal root ganglia, pancreas and gut.
    Cross-Reactivity (Details)
    Species reactivity (expected):most Mammals.
    Species reactivity (tested):Human and Rat.
    Characteristics
    Synonyms: Calcitonin gene-related peptide I, Alpha-type CGRP, CALC1, CGRP-I
    Purification
    Protein G Chromatography.
    Clone
    4901
    Isotype
    IgG2a
    Top Product
    Discover our top product CALCA Primary Antibody
  • Application Notes
    Immunocytochemistry: 1/50-1/100. Immunofluorescence and Immunohistochemistry: This antibody is an excellent tool forImmunohistochemistry and for multiple labeling immunofluorescence of peripheral tissuelike stomach, intestine, pancreas, sensory ganglia, and all the regions of the body that areinnervated by primary afferent neurons as well as central nervous tissue. Suggested Positive Controls: Dorsal root ganglia, pancreas and gut. Not recommended for Western blotting.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol
    Storage
    -20 °C
    Storage Comment
    Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))
    Alternative Name
    CGRP / CALCA (CALCA Products)
    Synonyms
    CALC1 antibody, CGRP antibody, CGRP-I antibody, CGRP1 antibody, CT antibody, KC antibody, CALC antibody, CALCA antibody, CALC3 antibody, ci-ct antibody, calca antibody, CA antibody, CGRP-1 antibody, Calc antibody, Calc1 antibody, Cgrp antibody, Ct antibody, Ctn antibody, calcitonin antibody, CAL6 antibody, Cal1 antibody, RATCAL6 antibody, CGRPI antibody, calc antibody, cgrp antibody, zgc:92886 antibody, calcitonin related polypeptide alpha antibody, calcitonin related polypeptide beta antibody, calcitonin-related polypeptide alpha antibody, calcitonin antibody, calcitonin/calcitonin-related polypeptide, alpha antibody, calcitonin-related polypeptide beta antibody, calcitonin gene-related peptide 2 antibody, CALCA antibody, CALCB antibody, ci-ct antibody, calca antibody, Calca antibody, LOC100008771 antibody
    Background
    Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985). CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003). CGRP antibodies have been used successfully in Immunoneutralization (Wong et al., 1993)Synonyms: Alpha-type CGRP, CALC1, CGRP-I, Calcitonin gene-related peptide I
    Gene ID
    796
    UniProt
    P06881
    Pathways
    Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour
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