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Progesterone Receptor antibody (pSer190)

PGR Reactivity: Human WB, IHC (fro) Host: Mouse Monoclonal 1154 unconjugated
Catalog No. ABIN371834
  • Target See all Progesterone Receptor (PGR) Antibodies
    Progesterone Receptor (PGR)
    Binding Specificity
    • 16
    • 16
    • 15
    • 14
    • 13
    • 12
    • 11
    • 10
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer190
    Reactivity
    • 240
    • 42
    • 38
    • 16
    • 15
    • 8
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 182
    • 60
    • 1
    • 1
    Mouse
    Clonality
    • 176
    • 68
    Monoclonal
    Conjugate
    • 121
    • 21
    • 11
    • 11
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This Progesterone Receptor antibody is un-conjugated
    Application
    • 177
    • 90
    • 57
    • 32
    • 29
    • 26
    • 26
    • 25
    • 18
    • 18
    • 17
    • 12
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This antibody is specific for the ~90k PR-A isoform and the ~120k PR-B isoform phosphorylated at Ser190. Immunolabeling is blocked by the Phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Characteristics
    Synonyms: PR, PGR, NR3C3, Nuclear Receptor Subfamily 3 Group C Member 3
    Purification
    Affinity Chromatography on Protein G.
    Immunogen
    Phosphopeptide corresponding to amino acid residues surrounding the Phospho-Ser190 ofHuman progesterone Receptor.
    Clone
    1154
    Isotype
    IgG1
    Top Product
    Discover our top product PGR Primary Antibody
  • Application Notes
    Western Blot: 1/1000. Immunohistochemitry (Frozen Sections, unpublished observations): 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Storage
    -20 °C
    Storage Comment
    Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    Progesterone Receptor (PGR)
    Alternative Name
    Progesterone Receptor (PGR Products)
    Synonyms
    NR3C3 antibody, PR antibody, 9930019P03Rik antibody, BB114106 antibody, ENSMUSG00000074510 antibody, PR-A antibody, PR-B antibody, XPR-1 antibody, pgr antibody, xpr-2 antibody, LOC443444 antibody, PGR antibody, pg antibody, pr antibody, gb:dq017620 antibody, progesterone receptor antibody, progesterone receptor L homeolog antibody, PGR antibody, Pgr antibody, pgr.L antibody, pgr antibody
    Background
    There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer (Edwards, 2005). The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones (Attia et al., 2000, Lin et al., 2003). Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor (Clemm et al., 2000). Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.Synonyms: NR3C3, Nuclear Receptor Subfamily 3 Group C Member 3, PGR, PR
    Gene ID
    5241
    UniProt
    P06401
    Pathways
    Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration
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