Chemokine (C-C Motif) Receptor 1 (CCR1) antibody

Antigen: Chemokine (C-C Motif) Receptor 1 (CCR1)

Synonyms: CKR1, CD191, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN372407

Additional Information

Characteristics: Synonyms: C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CMKBR1, CMKR1, SCYAR1,HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP1 alphaReceptor, RANTES-R

Alternative name: CD191 / CCR1

Swiss-Prot: P32246

Immunogen: A synthetic peptide of human CCR1 protein.

Cross-Reactivity: Human, Mouse (Murine)

Isotype: IgG  (Matching secondary antibodies)

Description: This gene encodes a member of the beta chemokine receptor family, which is predicted tobe a seven transmembrane protein similar to G protein-coupled receptors. The ligands ofthis receptor include macrophage inflammatory protein 1 alpha (MIP1 alpha), regulated onactivation normal T expressed and secreted protein (RANTES), monocyte chemoattractantprotein 3 (MCP3), and myeloid progenitor inhibitory factor 1 (MPIF1). Chemokines and theirreceptors mediated signal transduction are critical for the recruitment of effector immunecells to the site of inflammation. Knockout studies of the mouse homolog suggested theroles of this gene in host protection from inflammatory response, and susceptibility tovirus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2,CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

Specificity: This antibody recognizes C-C Chemokine Receptor 1 (CCR1/CD191). Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse.

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western blot: 1-3 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.5 mg/ml

Purification: Aff - Purified

Buffer: PBS containing 0.2% Gelatin as stabilizer and 0.05% Sodium Azide aspreservative.

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Chemokines, Receptors

Restrictions: For Research Use only