Lymphocyte-Specific Protein 1 (LSP1) (AA 37-48) antibody

Antigen: Lymphocyte-Specific Protein 1 (LSP1)

Synonyms: WP34, pp52, LSP1, p50, Lsp-1

Epitope: AA 37-48

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN372498

Additional Information

Characteristics: Synonyms: Lymphocyte-specific protein 1, Protein pp52, 52 kDa phosphoprotein, Lymphocyte-specificantigen WP34, 47 kDa actin-binding protein

Alternative name: LSP1 / WP34

Swiss-Prot: P33241

Immunogen: Synthetic peptide (KLH coupled) corresponding to residues surrounding amino acids 37-48of human LSP1.

Cross-Reactivity: Human

Isotype: IgG  (Matching secondary antibodies)

Description: LSP1 is a 52kD leukocyte-specific protein expressed in B cells, T cells, macrophages andneutrophils. The protein binds F-actin through its carboxy-terminal actin-binding repeatand regulates cytoskeletal-related cellular movement such as polarization, chemotaxisand locomotion. LSP1 is a phospho-protein and has been identified as a major substrate ofMAP kinase and PKC in lymphocytes and neutrophils. The phosphorylation is possiblyrelated to its cytoskeletal regulation function.

Specificity: This antibody detects endogenous levels of LSP1 protein independent of phosphorylation. Species Reactivity: Tested: Human.

Application Details

Application Notes: Western Blot: 1/100. Immunohistochemistry on Paraffin Sections: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Purified

Buffer: 10 mM Sodium HEPES, pH 7.5 with 150 mM Sodium Chloride, BSA and 50%Glycerol.

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only