Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

CREB1 antibody (pSer133)

CREB1 Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Chicken, Sheep, Dog, Xenopus laevis, Non-Human Primate WB, IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN372604
  • Target See all CREB1 Antibodies
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Binding Specificity
    • 63
    • 29
    • 20
    • 17
    • 16
    • 16
    • 10
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer133
    Reactivity
    • 288
    • 210
    • 176
    • 33
    • 23
    • 17
    • 16
    • 13
    • 11
    • 10
    • 9
    • 8
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Chicken, Sheep, Dog, Xenopus laevis, Non-Human Primate
    Host
    • 264
    • 26
    • 1
    • 1
    Rabbit
    Clonality
    • 239
    • 53
    Polyclonal
    Conjugate
    • 148
    • 16
    • 13
    • 12
    • 11
    • 11
    • 11
    • 11
    • 11
    • 10
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    This CREB1 antibody is un-conjugated
    Application
    • 224
    • 100
    • 98
    • 74
    • 56
    • 56
    • 48
    • 47
    • 20
    • 17
    • 16
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    Specific for the ~45k CREB protein phosphorylated at Ser133. Immunolabeling is blocked by lambda-phosphatase treatment.
    Cross-Reactivity (Details)
    Species reactivity (expected):Bovine, Canine, Chicken, Human, Mouse, Sheep, Xenopus, Zebrafish and non-Human Primates.
    Species reactivity (tested):Rat.
    Purification
    Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
    Immunogen
    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser133 of rat CREB.
    Isotype
    IgG
    Top Product
    Discover our top product CREB1 Primary Antibody
  • Application Notes
    Western Blot: 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Target
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Alternative Name
    CREB1 (CREB1 Products)
    Synonyms
    creb antibody, CREB1 antibody, Creb1 antibody, CREB antibody, 2310001E10Rik antibody, 3526402H21Rik antibody, AV083133 antibody, Creb antibody, Creb-1 antibody, creb1 antibody, zgc:55598 antibody, cAMP responsive element binding protein 1 antibody, cAMP responsive element binding protein antibody, cAMP responsive element binding protein 1 S homeolog antibody, cAMP responsive element binding protein 1a antibody, CREB1 antibody, creb1 antibody, CREB antibody, Creb1 antibody, creb1.S antibody, creb1a antibody
    Background
    It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus (Karin and Hunter, 1995). The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulus-induced transcription factors (Montminy, 1997). This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory (Shaywitz and Greenberg, 1999, Silva et al., 1998). A variety of protein kinases including protein kinase A (PKA), mitogen-activated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser133), and phosphorylation of Ser133 are required for CREB-mediated transcription (Johannessen et al., 2004, Kornhauser et al., 2002).Synonyms: CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1
    Gene ID
    81646
    NCBI Accession
    NP_112279
    UniProt
    P15337
    Pathways
    TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
You are here:
Support