SLC6A3 antibody (C-Term)

Catalog No. ABIN372613

Product Details anti-SLC6A3 Antibody

Target: SLC6A3 (Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Non-Human Primate

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC6A3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Dot Blot (DB)

Specificity: Specific for the ~88 kDa DAT protein in Western blots.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse and non-Human Primates.

Purification: Affinity Chromatography using a SulfoLink® column matrix to which the peptide immunogen was coupled.

Immunogen: Peptide from the intracellular C-terminus region of human Dopamine Transporter (DAT), conjugated to keyhole limpet hemocyanin (KLH).

Isotype: IgG

Application Details

Application Notes: Western Blot (1/1000) of SDS-solubilized Human and Mouse striatal samples. Immunohistochemistry (Frozen Sections, Formaldehyde Fixed Tissue): 1/1000 with Monkey(Macaque) brain sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at-20 °C. For long term storage at -80 °C is recommended.

Target Details for SLC6A3

Target: SLC6A3 (Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3))

Alternative Name: SLC6A3 / DAT (SLC6A3 Products)

Synonyms: DAT antibody, SLC6A3 antibody, Dat1 antibody, DAT1 antibody, PKDYS antibody, solute carrier family 6 member 3 antibody, solute carrier family 6 (neurotransmitter transporter), member 3 antibody, Sodium-dependent dopamine transporter antibody, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 antibody, SLC6A3 antibody, slc6a3 antibody, dat-1 antibody, Slc6a3 antibody

Background: The dopamine transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001, Zhu et al., 2000, Zhu et al., 1999). Levels of DAT protein expression are altered by chronic drug administration (Wilson et al., 1996).Synonyms: DA transporter, DAT1, Sodium-dependent dopamine transporter, Solute carrier family 6 member 3

Gene ID: 6531

NCBI Accession: NP_001035

UniProt: Q01959

Pathways: Dopaminergic Neurogenesis