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GABRA6 antibody (Cytoplasmic Loop)

GABRA6 Reactivity: Human, Rat, Mouse, Cow WB, DB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN372635
  • Target See all GABRA6 Antibodies
    GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))
    Binding Specificity
    • 15
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Loop
    Reactivity
    • 41
    • 25
    • 21
    • 6
    • 4
    • 4
    • 1
    Human, Rat, Mouse, Cow
    Host
    • 46
    • 1
    Rabbit
    Clonality
    • 47
    Polyclonal
    Conjugate
    • 17
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GABRA6 antibody is un-conjugated
    Application
    • 34
    • 13
    • 13
    • 12
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Dot Blot (DB)
    Specificity
    Specific for the ~57k Alpha-6 subunit of the GABAA Receptor in Western blots of Rat brain membrane fractions. Also recognizes the alpha-6 subunit of GABAA-R in Bovine, Human amnd Mouse brain extracts. Does not recognizes GABAA-R subunits as reactivity is eliminated in alpha-6 knockout brain.
    Purification
    Affinity Chromatography.
    Immunogen
    Fusion protein from the cytoplasmic loop of the Alpha-6 subunit of Rat GABAA Receptor.
    Isotype
    IgG
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  • Application Notes
    Western Blot: 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Target
    GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))
    Alternative Name
    GABAA Receptor alpha 6 (GABRA6 Products)
    Synonyms
    LOC100224835 antibody, GABRA6 antibody, Gabra-6 antibody, alpha6 antibody, si:dkey-217k23.1 antibody, zgc:73148 antibody, gamma-aminobutyric acid type A receptor alpha 6 subunit antibody, gamma-aminobutyric acid type A receptor alpha6 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 antibody, gamma-aminobutyric acid (GABA) A receptor, alpha 6a antibody, Gabra6 antibody, GABRA6 antibody, gabra6a antibody
    Background
    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different Alpha-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003).Synonyms: GABRA-6, GABRA6, Gamma-Aminobutyric Acid Receptor subunit Alpha-6
    Gene ID
    29708
    NCBI Accession
    NP_068613
    UniProt
    P30191
    Pathways
    Synaptic Membrane
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