GRIA2 antibody (pSer880)

Catalog No. ABIN372656

Product Details anti-GRIA2 Antibody

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Binding Specificity: pSer880

Reactivity: Human, Rat, Mouse, Zebrafish (Danio rerio), Non-Human Primate

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIA2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody is specific for the ~100k phosphorylated at Ser880.

Cross-Reactivity (Details): Species reactivity (expected):Chicken, Human, Mouse, Zebrafish and non-Human Primates.
Species reactivity (tested):Rat.

Purification: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser880 of rat GluR2.

Isotype: IgG

Application Details

Application Notes: Western blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at-20 °C.

Target Details for GRIA2

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Alternative Name: Glutamate Receptor 2 / GLUR2 (GRIA2 Products)

Synonyms: GLUR2 antibody, GLURB antibody, GluA2 antibody, GluR-K2 antibody, HBGR2 antibody, GluR-2 antibody, GluR-B antibody, Glur-2 antibody, Glur2 antibody, GluR2 antibody, gluR-B antibody, glur2a antibody, gria2.1 antibody, zfGRIA2[a] antibody, glur2 antibody, glutamate ionotropic receptor AMPA type subunit 2 antibody, glutamate receptor, ionotropic, AMPA 2 antibody, glutamate receptor, ionotropic, AMPA2 (alpha 2) antibody, glutamate receptor, ionotropic, AMPA 2a antibody, glutamate receptor, ionotropic, AMPA 2 S homeolog antibody, GRIA2 antibody, Gria2 antibody, gria2a antibody, gria2.S antibody

Background: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990, Hollmann and Heinemann, 1994). The number of GluR2 subunits in the AMPA receptor complex affects the Ca2+ permeability, rectification and single-channel conductance of AMPA receptors. Ser880 has been identified as the PKC phosphorylation site within the C-terminal region of GluR2 and has been shown to differentially regulate the interaction of the PDZ domain-containing proteins GRIP1 and PICK 1 (Matsuda et al., 1999)Synonyms: AMPA-selective glutamate receptor 2, AMPA2, GRIA2, GluR-B, GluR-K2, Glutamate receptor ionotropic

Gene ID: 29627

NCBI Accession: NP_001077280

UniProt: P19491

Pathways: PI3K-Akt Signaling