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PAK1 antibody (pThr402)

PAK1 Reactivity: Human, Rat, Mouse, Cow, Dog WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN372696
  • Target See all PAK1 Antibodies
    PAK1 (P21-Activated Kinase 1 (PAK1))
    Binding Specificity
    • 34
    • 17
    • 15
    • 13
    • 10
    • 10
    • 9
    • 9
    • 8
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr402
    Reactivity
    • 173
    • 94
    • 82
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Rat, Mouse, Cow, Dog
    Host
    • 166
    • 4
    • 1
    • 1
    Rabbit
    Clonality
    • 160
    • 13
    Polyclonal
    Conjugate
    • 90
    • 10
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    This PAK1 antibody is un-conjugated
    Application
    • 116
    • 66
    • 45
    • 39
    • 39
    • 34
    • 32
    • 14
    • 11
    • 10
    • 10
    • 6
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Specificity
    This antibody recognizes the ~68k to ~70k PAK protein phosphorylated at Thr402. The immunolabeling of PAK is completely eliminated by lambda-phosphatase treatment.
    Cross-Reactivity (Details)
    Species reactivity (expected):Human, Bovine, Canine and Mouse.
    Species reactivity (tested):Rat.
    Purification
    Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
    Immunogen
    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr402 of Rat p21 activated kinase 2 (PAK-2).
    Isotype
    IgG
    Top Product
    Discover our top product PAK1 Primary Antibody
  • Application Notes
    Western blot: 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Nie, Lilley, Pan, Faruque, Liu, Zhang, Sanes, Han, Shi: "SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic ? cells." in: Molecular and cellular biology, Vol. 33, Issue 13, pp. 2527-34, (2013) (PubMed).

  • Target
    PAK1 (P21-Activated Kinase 1 (PAK1))
    Alternative Name
    PAK1 (PAK1 Products)
    Synonyms
    X-PAK1 antibody, XPak1 antibody, pak antibody, pak-1 antibody, pakalpha antibody, PAKalpha antibody, AW045634 antibody, PAK-1 antibody, Paka antibody, p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog antibody, p21 (RAC1) activated kinase 1 antibody, p21 protein (Cdc42/Rac)-activated kinase 1 antibody, Serine/threonine-protein kinase pak-1 antibody, pak1.S antibody, PAK1 antibody, Pak1 antibody, pak-1 antibody
    Background
    In mammals, there are several identified isoforms of p21-activated protein kinases or PAKs: alpha-PAK (also known as PAK-1) and beta-PAK (also known as PAK-3) are mostly brain-specific, while gamma-PAK (also known as PAK-2) is expressed ubiquitously (Jakobi et al., 2003). Mutations of the gene coding for PAK-3 are associated with X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004). PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death (Jakobi et al., 2003, Walter et al., 1998). Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK (Jakobi et al., 2000).Synonyms: Alpha-PAK, Beta-PAK, Gamma-PAK, OPHN3, Oligophrenin-3, PAK 1, PAK 2, PAK 3, PAK alpha, PAK beta, PAK gamma, PAK-1, PAK-2, PAK-3, PAK65, Serine/threonine-protein kinase PAK 1, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase PAK 3, p21-activated kinase 1, p21-activated kinase 2, p21-activated kinase 3, p58, p65-PAK
    Gene ID
    5058
    NCBI Accession
    NP_001122092
    UniProt
    Q13153
    Pathways
    MAPK Signaling, RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Embryonic Body Morphogenesis
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