SCNN1G antibody (C-Term)

Catalog No. ABIN372870

Product Details anti-SCNN1G Antibody

Target: SCNN1G (Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCNN1G antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detetcs Human SCNN1G at C-term.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide corresponding to C-terminal residues of Human SCNN1G (Amiloride- sensitive sodium channel gamma-subunit).

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry on paraffin sections: 5 μg/mL. Western blot: 1 μg/mL. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.01 % Sodium Azide and 50 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for SCNN1G

Target: SCNN1G (Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G))

Alternative Name: ENAC gamma / SCNN1G (SCNN1G Products)

Synonyms: ENaC antibody, BESC3 antibody, ENaCg antibody, ENaCgamma antibody, PHA1 antibody, SCNEG antibody, scnn1g antibody, MGC81424 antibody, SCNN1G antibody, enacg antibody, gammaxENaC-A antibody, pha1 antibody, [g]ENaC antibody, GAMMA-ENAC antibody, gamma XENaC antibody, gamma-ENaC antibody, gamma2xENaC-A antibody, scneg antibody, sodium channel epithelial 1 gamma subunit antibody, sodium channel, nonvoltage-gated 1, gamma antibody, sodium channel, non voltage gated 1 gamma subunit L homeolog antibody, sodium channel, nonvoltage-gated 1 gamma antibody, sodium channel, non voltage gated 1 gamma subunit S homeolog antibody, Scnn1g antibody, SCNN1G antibody, scnn1g antibody, scnn1g.L antibody, scnn1g.S antibody

Background: Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel's syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).Synonyms: Amiloride-sensitive sodium channel subunit gamma, ENaCG, Epithelial Na(+) channel subunit gamma, Gamma-ENaC, Gamma-NaCH, Nonvoltage-gated sodium channel 1 subunit gamma, SCNEG

Gene ID: 6340

NCBI Accession: NP_001030

UniProt: P51170