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Bone Morphogenetic Protein 4 (BMP4) antibody

Antigen

Bone Morphogenetic Protein 4 (BMP4)
Synonyms ZYME, BMP2B, OFC11, BMP2B1, MCOPS6, Bmp-4, Bmp2b, Bmp2b1, Bmp2b-1, BOMPR4A, bmp-4, zbmp-4, MGC100779, zgc:100779, BMP4, BMP-4, xbmp4, XBMP-4, Bmp4, MGC127497, zyme, bmp2b, bmp2b1, bmp4
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Application
Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Catalog no. ABIN373072
Quantity 0.1 ml  (0.2 mg/ml)  (Variants)
Price 195.00 $   Plus shipping costs $35.00
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Availability Ships within 7 to 10 Business Days

Additional Information
Application Details Alternatives Secondary Antibodies Variants back to top

Characteristics Synonyms: BMP2B, BMP-2B, BMP-4, DVR4, Bone morphogenetic protein 4
Alternative name BMP4
Gene ID 652
Swiss-Prot P12644
Immunogen Recombinant human BMP4 protein
Cross-Reactivity Human
Description BMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurallyrelated signaling proteins. Members of this superfamily are widely represented throughoutthe animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF beta superfamily are disulfide-linked dimers composed of two 12-15 kDapolypeptide chains. As implied by their name, BMPs initiate, promote and regulate bonedevelopment, growth, remodeling and repair. Smad1 translocation to the nucleus isobserved after the addition of BMP4 (also designated BMP2B), suggesting that BMP4 mayplay a role in activation of the Smad pathway. BMP is secreted into the extracellular matrix. BMP4 is one of nine structurally related BMPs belonging to the transforming growth factorbeta superfamily of secreted proteins. BMP4 has important roles as a signaling molecule inthe developing central and peripheral nervous system, musculature and skeleton. BMPalso plays an important role in early tooth morphogenesis.
Specificity This antibody detects BMP4. Cellular localisation: Cytoplasmic. Species: Human. Others not tested. Add. Information: Molecular Weight: 45kDa

Application Details
Alternatives Secondary Antibodies Variants back to top

Application Notes Immunohistochemistry on Paraffin Sections: 1/50 for 30 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer,pH 6.0 for 10 min followed by cooling at RT for 20 min. Positive Control: Bone marrow. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 0.2 mg/ml
Purification Purified
Buffer 10 mM PBS, pH 7.4 with BSA and Sodium Azide
Storage Store the antibody undiluted at 2-8°C. Shelf life: one year from despatch.
Research Area Organogenesis, Growth Factors, Angiogenesis, Signaling
Restrictions For Research Use only

Alternatives
Application Details Secondary Antibodies Variants back to top

Alternatives for antigen "Bone Morphogenetic Protein 4 (BMP4)", type "Antibodies"
Hosts Rabbit (35), Mouse (22)
Reactivities Human (50), Mouse (Murine) (25), Rat (Rattus) (21), Chicken (3), Rabbit (2), Cow (Bovine) (1), Dog (Canine) (1), Pig (Porcine) (1), Xenopus laevis (1)
Applications Western Blotting (WB) (34), Flow Cytometry (FACS) (19), Immunofluorescence (IF) (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (18), ELISA (16), Enzyme Immunoassay (EIA) (3), Immunocytochemistry (ICC) (3), Immunohistochemistry (IHC) (3), Immunoprecipitation (IP) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Neutralization (Neut) (2), Blocking Antibody (Inhibition) (1), Functional Studies (Func) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitopes N-Term (1)